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MODELING AND INHIBITION OF VEGF-C/VEGFR2 ACTIVE SITE. Mohamed El Mansy Matthew Flister Denan Wang. Under supervision of Professor Daniel Sem. Angiogenesis. INTRODUCTION. VEGF. oxygen and nutrients. Anti apoptosis. Targeting VEGF is a promising anti-cancer treatment. Blood. Tumors.

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modeling and inhibition of vegf c vegfr2 active site

MODELING AND INHIBITION OF VEGF-C/VEGFR2 ACTIVE SITE

Mohamed El Mansy

Matthew Flister

Denan Wang

Under supervision of

Professor Daniel Sem

introduction

Angiogenesis

INTRODUCTION
  • VEGF

oxygen and nutrients

  • Anti apoptosis

Targeting VEGF is a promising anti-cancer treatment.

Blood

Tumors

chemotherapy and other drugs

slide3

http://www.sigmaaldrich.com

Several signaling pathways are activated by VEGFR2, including the PI 3- kinase/Aktpathway and MAP kinases such as ERK1 and ERK2

protein structure
Protein Structure

VEGF-C/VEGFR2

Complex of four domains, two

VEGFR2 bound to VEGFdimer

  • VEGF-C
    • Anti-parallel homodimer,
    • two cysteine disulfide bonds
slide7

Future work

Dr. Wilkinson’s lab has recently been working on whether a second gene influences how well VEGF can activate its receptor (KDR).

They can then use protein called ECSCR measure sensitivity to VEGF.

Future research in anti-VEGF therapies will most likely combine anti-tumor therapy with anti-VEGF treatment at the correct dosage and time.