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Neural Effects of Extreme Drinking on 21st Birthday Study

This study led by Dr. Kerns aims to investigate the neural impact of extreme drinking in young adults, particularly on their 21st birthdays. Using MRI scans, researchers assess cognitive changes. Data from 10 participants showed significant drinking levels and activities during celebrations. The ultimate goal is to recruit 70 participants, analyze brain activity, and identify brain changes related to extreme drinking.

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Neural Effects of Extreme Drinking on 21st Birthday Study

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  1. 21st Birthday Study Angela Freeman

  2. Overview of study… • Principal Investigator: Dr. Kerns • Main goal: to study neural effects of extreme drinking in young adults • Single occurrence of extreme drinking occurs on 21st birthday • Young adults may attempt 21 drinks/shots on bday

  3. Continued… • Does this drinking episode produce any cognitive changes? • Will be using both the functional MRI and structural MRI

  4. Testing after extreme drinking • fMRI=examining decreased brain activity in the hippocampus as well as the prefrontal cortex • While completing a long-term memory cognitive task • Structural MRI=studying the decreased brain volume of hippocampus/prefrontal cortex

  5. Overview of Subjects • Goal: 70 participants • Subjects: young adults who are turning 21 years old • Subjects must be celebrating/drinking on 21st birthday • Will participate in three separate interviews

  6. Screening • Must make sure participant is eligible • Initial participant screening form • Would complete screening form via phone • Since conducting a MRI scan must take safety precautions

  7. Continued… • Screened for… • Pacemaker /Mechanical Device • Body piercings • Braces-can distort data • Welding? • Claustrophobic?

  8. First Interview • Responsible for conducting first interview • Length: 1.5 to 2 hours • Many different interviews • Hangover Symptoms Scale • Lifetime Drinking History • Diagnostic Interview Schedule for DSM-IV

  9. Hangover Symptoms Scale • Hangover symptoms last 12 months • Ex. “In the past 12 months when you drank alcohol, how often did you feel more tired than usual the next morning?” • Answer options: • 1. Never • 2. Occasionally • 3. About half the time • 4. Most of the time • 5. Every time I drink alcohol

  10. Lifetime Drinking History • When first phase of drinking • Anymore phases of drinking? • Example: high school, or when first start college • To get an idea of drinking history

  11. Continued… • Start with beginning phase • Ask about life events • Ask if event was positive, negative, or neutral • How often would drink alcohol/how much? • % of beer, liquor, or wine • Drink alone/with others

  12. Diagnostic Interview • Very lengthy • Has different sections • Demographics, Generalized Anxiety Disorder, Depression, Nicotine Dependence • Longest interview • Mainly yes/no questions

  13. MRI training • Brain scans held at Brain Imaging Center • Had to become a Level One MR Personnel • Level 3 or 4 Personnel must accompany me • Would assist the graduate student with various tasks

  14. MRI Training • Training consisted of: • Receive tour of the facility • Location of emergency buttons and switches • Certification-safety training quiz

  15. Scan time! • Very important take all metal off!! • Scanner operator must take all metal off • Scanner=almost two hours • Cognitive tasks while in scanner • Show video first • Planet Earth

  16. First task • Imagery task • See 2 words at a time • Form a mental image • If a excellent image press with right index finger • If poor image press with right middle finger • After scan will ask about words saw in scanner

  17. Second task • N-Back Task • See a series of circles on screen • For every circle decide if it was in same spot three circles ago • Right index finger=same • Right middle finger=different • Measures working memory

  18. Example SAME

  19. After scan • Need to complete another cognitive task • Basically ask about words saw in scanner • Asked participants to form mental image • After this participant done with first scan!

  20. Interviews • 2nd interview • Ask about birthday celebration • What occurred/how much standard drinks consumed? • Data first 10 participants • Average number of standard drinks=13.2 • 80%=10 or more drinks • 20%=21 or more drinks (max = 28) • Activities participated in • Bar-hopping, dancing, did you embarrass yourself?, card games • Who celebrate with?

  21. Third Interview • 5 weeks after second scan • Final scan • Assess how much had to drink previous 5 weeks

  22. Goals of study • Recruit more participants • Goal=70 all together • Analyze brain activity/structure • Discover any changes in brain?

  23. THE END!!!!!

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