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Assessing effects of prenatal

Assessing effects of prenatal PAH exposure on birth outcomes and neurocognitive development among a cohort of Polish mothers and newborns.

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Assessing effects of prenatal

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  1. Assessing effects of prenatal PAH exposure on birth outcomes and neurocognitive development among a cohort of Polish mothers and newborns. Ulka Bawle*, Wieslaw Jedrychowski**, Robin Whyatt*, David Camann***, John Spengler***, Tom Dumyahn***, Frederica Perera* */ Center for Children’s Environmental Health, Columbia University, New York, USA **/Chair of Epidemiology and Preventive Medicine, Coll.Med.. Jagiellonian University, Krakow, Poland ***/

  2. What is the role of early life exposures to PAH?

  3. D - Developmental C - Cancer G - Genetic damage

  4. HEALTH HAZARDS DUE TO PAH COMPONENTS Macromolecules Biotransformation PAHs Epoxides Mixed-function oxidases P-450 enzymes Aryl hydrocarbon hydrolase (AHH) DNA Impairment of fetal and early childhood growth and development

  5. Research Design of study “Vulnerability of the Fetus/Infant to PAH, PM2.5 and ETS” Recruitment in Pregnancy I tri. II tri. III tri. Deli- 3 m 6 m 9 m 12 m n=96 n=400 very

  6. Characteristics of recruited pregnant women: age of women N = 30 N = 105

  7. Characteristics of recruited pregnant women: by educational level and marital status N = 30 N = 105

  8. Characteristics of recruited pregnant women: number of pregnancies N = 30 N = 105

  9. PAH concentrations in low and high polluted areas of Krakow (N=30). Air monitoring over 48 hours. ng/m3

  10. Mean 56,729 Median 56,758 Standard deviation 26,181 (Q3-Q1)/2 14,652 PM2.5concentration in KrakowN = 30

  11. PAH concentrations in Krakow and New York City ng/m3

  12. Contribution of various chemical substances (in %) in the total PAH concentration in Krakow and New York City Krakow New York City

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