All pathways - PowerPoint PPT Presentation

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  1. Early-Mid G1 Restriction Pt. Late G1 S All pathways Click to continue Mitogenic signals  Ras DNA Repair DNA Damage BRCA2 Senescence / Apoptosis Red = inhibits cell growth Line = inhibits next step mdm2 ATM CDK2 Cyclin A myc Click on any yellow box Click on any yellow box Click on any yellow box BCL-2 PKB Arrow = leads to next step DNA Replication Bax CDK4/6 Cyclin D Return to main page End show Go to next pathway Previous pathway p53 Green = increases cell growth TGF-β p16INK4 p14ARF p21 TGF-β myc CDK2 Cyclin E p27 Master Switch Rb E2F E2F DNA Replication Factors

  2. Early-Mid G1 Restriction Pt. Late G1 S All pathways Mitogenic signals  Ras DNA Repair DNA Damage BRCA2 Senescence / Apoptosis mdm2 ATM CDK2 Cyclin A myc BCL-2 PKB DNA Replication Bax CDK4/6 Cyclin D p53 TGF-β p16INK4 p14ARF p21 TGF-β myc CDK2 Cyclin E p27 Master Switch Rb E2F E2F DNA Replication Factors

  3. Early-Mid G1 Restriction Pt. Late G1 S Mitogen Mitogenic signals  Ras CDK2 Cyclin A myc DNA Replication CDK4/6 Cyclin D CDK2 Cyclin E Master Switch Rb E2F E2F DNA Replication Factors

  4. Early-Mid G1 Restriction Pt. Late G1 S myc DNA Repair Senescence / Apoptosis CDK2 Cyclin A myc BCL-2 DNA Replication Bax CDK4/6 Cyclin D p53 p16INK4 p14ARF p21 myc CDK2 Cyclin E Master Switch Rb E2F E2F DNA Replication Factors

  5. Early-Mid G1 Restriction Pt. Late G1 S Master Switch CDK2 Cyclin A DNA Replication CDK2 Cyclin E Master Switch Rb E2F E2F DNA Replication Factors

  6. Early-Mid G1 Restriction Pt. Late G1 S DNA damage DNA Repair DNA Damage BRCA2 Senescence / Apoptosis mdm2 ATM BCL-2 Bax p53 p21 CDK2 Cyclin E

  7. Early-Mid G1 Restriction Pt. Late G1 S PKB DNA Repair Senescence / Apoptosis BCL-2 PKB Bax p53 p21 CDK2 Cyclin E p27

  8. Early-Mid G1 Restriction Pt. Late G1 S TGF-β Senescence / Apoptosis TGF-β p16INK4 TGF-β CDK2 Cyclin E p27