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Impact of PS Function on Synaptic Density in Cortical Neurons: A 3D Confocal Analysis

Explore how lack of PS function affects spine density and PSD-95/DCC clusters in cortical neurons through 3D confocal imaging. Representative images show clustering differences in Wt and Compound E-treated neurons.

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Impact of PS Function on Synaptic Density in Cortical Neurons: A 3D Confocal Analysis

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  1. PSD-95 DCC Overlay Wt Compound E Figure 1S Parent et al. Lack of PS function increases spine density, PSD-95 and DCC clusters. Representative 3D reconstitution confocal images of cortical neurons are taken from 12 stacks. PSD-95 and DCC staining are shown respectively for Wt (top panel) and Wt neurons treated with Compound E (bottom panel). Synaptic clusters of PSD-95 (green) and DCC (red) are visualized as yellow overlay (left panel).

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