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King Henry VIII and his six wives. King Henry VIII of England married six times in an attempt to have a legitimate male heir to the English throne . Henry VIII blamed his wives for their inability to produce a son. Was Henry correct in blaming his wives? Explain. .

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King henry viii and his six wives

King Henry VIII

and his six wives

King Henry VIII of England married six times in an attempt to have a legitimate male heir to the English throne. Henry VIII blamed his wives for their inability to produce a son.

Was Henry correct in blaming his wives? Explain.


King henry viii and his six wives

Sex Determination in Humans:

Phenotype: 50% female , 50% male

Genotype:50% XX , 50% XY


King henry viii and his six wives

Prince William and Kate Middleton

The firstborn of Prince

Williamand Kate Middleton

will be heir to the throne,

whether it’s a boy or a girl

under the new succession

rules.


Sex linked inheritance
Sex-Linked Inheritance

  • Sex linked traits: Occur in humans, for which genes are on the X chromosome.

  • Each X-chromosome in the female will have one allele for a gene for a total of 2 alleles per gene

  • Because Males have only one X-chromosome they will only have one allele for a particular gene.

Female

Male


Sex linked inheritance1
Sex-Linked Inheritance

  • Types of inheritance:

    X-linked Dominant: dominant allele carried on one or both of the X-chromosomes will cause expression of the phenotype

    X-linked Recessive:recessive alleles must be present on bothX-chromosomes for a woman in order for the phenotype to be expressed, whereas a man only needs one recessive allele

Recessive allele

Dominant allele


Sex linked disorders
Sex- Linked Disorders

  • There are various disorders that arise from sex-linked inheritance. (Note: the disorder is considered to be the phenotype).

Haemophilia

Severe Combined Immunodeficiency


Colour blindness
Colour Blindness

The gene that causes colour blindness is on the X chromosome.


Sex linked inheritance problem
Sex-linked Inheritance Problem:

  • Color blindness is an sex-linked recessive disorder. Suppose a heterozygous female (carrier) is crossed with a normal male. What would be the genotype and phenotype proportions of the F1 generation?

Defective allele

Xh

X H

Phenotype: 2 normal females

1 normal male

1 color blind male (XhY)

X H

X H

Xh

X H

XH

Y

X H

Y

Xh

Y

Genotype: 25% XHXH

25% XH Y

25% XhXH

25% Xh Y