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Explore the effects of folate concentrations on IC50 values for 5-MeTHF, FA, and THF, with significant findings on folate sensitivity in physiological conditions.
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0.023 0.023 0.23 0.23 2.3 2.3 23 c 23 3.84 20.8 104 1.3 1.8 4.2 1 1.1 0.7 1.2 1.3 1.18 Table 2S 5-Me-Tetrahydrofolate (5-MeTHF) Folic acid (FA) Tetrahydrofolate (THF) IC50s (nM) in physiological folate (5-Me-THF 0.023 µM) IC50s (nM) in physiological folate (FA 0.023 µM) Increased factor of IC50sa in presence of 0.23, 2.3 and 23 µM FA IC50s (nM) in physiological folate (THF 0.023 µM) Increased factor of IC50a in presence of 0.23, 2.3 and 23 µM of THF Increased factor of IC50sa in presence of 0.23, 2.3 and 23 µM of THF 23 0.023 0.23 2.3 0.31+0 PM b 0.3+0.1 5.6 23.3 33.5 0.26+0 1.3 1.4 ND 0.22+0 1.7 2.52 3.2 0.23+0 0.16+0 0.98 1.1 ND CCG b 36.5+3.5 0.91 1.3 28.5+3.5 1.01 0.97 ND MTX 0.94 31.0+1 47.81+7.2 0.98 1.25 ND AMP 1.2 51.2+1.8 46.4+9.8 0.87 1.4 TMX ND 3.95+0.8 1.01 1.3 1.7 2.6+0.8 0.97 1.0 1.2 3.1+0.11 1.1 0.8 aIncrease factor of IC50s represents the ratio of IC50 in physiological folate condition versus the IC50 in presence of high folate condition. bIncrease value of PM and CCG in bold are all statistically significant (p<0.05) c concentration of 23 uM of 5-Me-THF was inhibitory
