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Bedside Sensory Testing. A set of standardized procedures using standardized equipment to conduct basic sensory testing with minimum cost and patient burden ‘Kits’ have been developed and partially validated with procedures and equipment for osteoarthritis (OA) and post-herpetic neuralgia (PHN).

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bedside sensory testing
Bedside Sensory Testing
  • A set of standardized procedures using standardized equipment to conduct basic sensory testing with minimum cost and patient burden
  • ‘Kits’ have been developed and partially validated with procedures and equipment for osteoarthritis (OA) and post-herpetic neuralgia (PHN)
bst procedures
BST Procedures
  • Local pressure pain threshold (PPT)
  • Distal PPT
  • Cold allodyia
  • Mechanoreceptive function (light touch threshold; LTT)
  • Tourniquet test (for diffuse noxious inhibitory control; DNIC)

PHN only

  • Punctate hyperalgesia
  • Dynamic mechanical allodynia
  • Temporal summation (wind-up)
can dnic predict analgesic efficacy of naproxen
Can DNIC predict analgesic efficacy of naproxen?

P<.001

SES=.77

P<.001

SES=.43

P<.05

SES=.34

OA subjects with dysfunctional DNIC showed greater discrimination of naproxen from placebo.

Consistent with Yarnitsky’s (2012) report that poor DNIC function predicted response to duloxetine in PHN.

can dnic predict analgesic efficacy of milnacipran
Can DNIC predict analgesic efficacy of milnacipran?

P<.001

P<.001

P<.001

OA subjects’ DNIC made no difference in open-label treatment with milnacipran (double-blind period showed no efficacy net vs. placebo either)

value of standardized bst
Value of Standardized BST
  • Variation in sensory testing procedures increases error. Solution: standardization
  • Many new treatments only demonstrate superiority in a sub-population. Solution: identify mechanisms for targeted treatment
  • RPC study underway using BST with PHN
  • Different tests in the BST toolbox may predict efficacy of different treatments in different populations