Epidemiology and Prevention of Viral Hepatitis A to E: Hepatitis E Virus - PowerPoint PPT Presentation

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Epidemiology and Prevention of Viral Hepatitis A to E: Hepatitis E Virus PowerPoint Presentation
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Epidemiology and Prevention of Viral Hepatitis A to E: Hepatitis E Virus
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Epidemiology and Prevention of Viral Hepatitis A to E: Hepatitis E Virus

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  1. Epidemiology and Prevention of Viral Hepatitis A to E:Hepatitis E Virus Division of Viral Hepatitis

  2. Geographic Distribution of Hepatitis E Outbreaks or Confirmed Infection in > 25% of Sporadic Non-ABC Hepatitis

  3. Hepatitis E – Epidemiologic Features • Most outbreaks associated withfecally contaminated drinking water • Minimal person-to-person transmission • U.S. cases usually have history of travel to HEV-endemic areas

  4. Hepatitis E – Clinical Features Incubation period:Average 40 days Range 15-60 days Case-fatality rate:Overall, 1%-3% Pregnant women, 15%-25% Illness severity:Increased with age Chronic sequelae:None identified

  5. Hepatitis E Virus Infection Typical Serological Course Symptoms IgG anti-HEV ALT Titer Virus in stool IgM anti-HEV 0 1 2 3 4 5 6 7 8 9 10 11 12 13 Weeks after Exposure

  6. Prevention and Control Measures for Travelers to HEV – Endemic Regions • Avoid drinking water (and beverages with ice) of unknown purity, uncooked shellfish, and uncooked fruit/vegetables not peeled or prepared by traveler • IG prepared from donors in Western countries does not prevent infection • Unknown efficacy of IG prepared from donors in endemic areas • Future vaccine (?)

  7. CDC – Educational and Training Resources • Website: www.cdc.gov/hepatitis • Toll-free information: 888-4HEPCDC (888-443-7232) • Web-based HCV training for professionals (http://www.cdc.gov/ncidod/diseases/hepatitis/training/index.htm) • Brochures, posters, slide sets, videos (http://www.cdc.gov/ncidod/diseases/hepatitis/resource/index.htm)