Anti-Depressant Medications. Brian Ladds, M.D. Outline. Earliest meds: MAOI TCA Neurotransmitter emphasized: NOR More recent meds: SSRI Neurotransmitter emphasized: SE. Discovery of Anti-Depressants. Historical Serendipity: An early anti-TB medication was noted incidentally to have:
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Brian Ladds, M.D.
MAOI and TCA are thought to bring about an anti-depressant effect by:
TCA also block post-synaptic: