1 / 8

National Database for Autism Research NDAR Matthew McAuliffe, Ph.D. NDAR Science Coordinator

National Database for Autism Research NDAR Matthew McAuliffe, Ph.D. NDAR Science Coordinator. NIMH, CIT. Vision and Goals. Vision:

kalli
Download Presentation

National Database for Autism Research NDAR Matthew McAuliffe, Ph.D. NDAR Science Coordinator

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. National Database for Autism ResearchNDARMatthew McAuliffe, Ph.D.NDAR Science Coordinator NIMH, CIT

  2. Vision and Goals Vision: To shorten the time for discovery of causes and treatments for autism by establishing a national data resource for collaboration in autism research and clinical practice. Goals: • Promote the sharing of research data via the BIRN infrastructure • Utilize the latest advances in bioinformatics technology • Broaden access to knowledge across domains • Provide powerful analysis tools • Develop standards to allow comparisons across studies

  3. NDAR 1.1 Functional Architecture NDAR System BIRN Services & Resources Clinical Assessments (OpenClinica) Neuroimaging Genomics Subject Tracking & Management Image Analysis Microarray Analysis Security Image Processing Common Measures Genetics Analysis Portal Image data access Study Management Grid Computing Collaboration Data Integration Query and Reporting Data Storage Management User Management Data Integration Tools Auditing

  4. NDAR Assessments – OpenClinica

  5. NDAR Assessments Forms(40 forms completed to date*) ADOS Modules (1-4) Adverse Events Log Autism Diagnostic Interview – Revised (ADI-R) Clinical Global Impressions Scale (CGI) Clinical Judgment checklist Communication and Symbolic Behavior Scale (Caregiver, Behavior Sample, Toddler Checklist) Demographic Information Differential Ability Scales DSM-IV Autism Spectrum Disorder Criteria Early Development Questionnaire M-CHAT MacArthur – Words and Sentences MacArthur – Words and Gestures Mullen Scales of Early Learning Peabody Picture Vocabulary Test (IIIA, IIIB) PDDI – Parent rating form REEL – 3 Regression Validation Interview Services Inventory Sensory Profile (Caregiver, Summary) Short Sensory Profile (Caregiver) Social Communication Questionnaire Social Responsive Scales Wechsler Intelligence Scale for Children – (WISC-IV) Vineland II – Survey Form * pending publisher agreements

  6. Z MID-SAG AC PC Y X Talairach & Other Atlas Transformation and Analysis – Using the BIRN version of MIPAV A. The Talairach atlas and other normalized atlases B. Putting all together: Talairach transform, Talairach atlas and segmentation for volume measurements of brain regions

  7. Current NDAR Vision – Release 1.0, Release 1.1, and Release 2.0 April 07 Nov 07 Oct 08 Release 1.0 Release 1.1 Release2.0 • Results • Clinical Assessments infrastructure • Portal and Security Infrastructure • Data migration foundation • Imaging infrastructure • Results • Data Migration infrastructure • Genetics foundation • Analysis and data mediation foundation • Results • Full integration of ’07 ACEs • Full integration of ’08 ACEs • Full integration of Autism Speaks • Support new communities • Vocabulary foundation • Analysis and data mediation infrastructure • Additional Clinical Assessments tools • Increased data migration • Added biomedical research tools Each release builds on the results from the prior release. Foundations are put in place, then a generic infrastructure is finalized so that NDAR can fluidly support new requirements as science transforms.

  8. For More Information • DEMONSTRATION ENVIRONMENT: https://nih-cit-stage-apps.nbirn.net/ • INFORMATIONAL WEBSITE: http://ndar.nih.gov • EMAIL QUESTIONS: ndar@mail.nih.gov

More Related