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Misc. Enterics and Gram- bacteria. Klebsiella. K. pneumoniae is most common pathogen Pneumonia ( nosocomial ) or UTI (makes urease ) Often associated with patient intubation Uses type 1 and type 3 (MRK) fimbriae Environmental organism Associated with plant roots, fixes nitrogen.

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klebsiella
Klebsiella

K. pneumoniaeis most common pathogen

Pneumonia (nosocomial) or UTI (makes urease)

Often associated with patient intubation

Uses type 1 and type 3 (MRK) fimbriae

Environmental organism

Associated with plant roots, fixes nitrogen

serratia
Serratia
  • S. marcescensis most common human pathogen
  • Opportunistic pathogen
  • Death knell of nosocomial pneumonia
  • Produces proteases that degrade host tissue
  • Hydrophobic cell surface adheres to medical plastics
  • Causes corneal ulcers in contact wearers
  • Often produces pink/orange pigment called prodigin
      • Type 1 and type 3 fimbriae probably evolved from common Serratiafimbriae
proteus
Proteus
  • P. mirabilis is most common pathogen
  • Primarily urinary tract infections
  • Proteus swarms-highly mobile
    • If you inoculate small point on agar plate proteus will swim out to form a large ring
  • Very strong urease producer-renal calculi
campylobacter
Campylobacter

Gram - bacterium grows at 42°C in High CO2, low oxygen

C. jejuniis most common human pathogen-gastroenteritis, bloody diarrhea can last for 1 week

Causes tissue damage in jejunum

Virulence factors include LPS, adhesins and flagella catalase and oxidase

Can spread, but is self-limiting

C. fetus expresses S protein that prevents complement activity and phagocytosis

Disseminates to blood and other systems readily

Immunocompromised patients are most affected

helicobacter
Helicobacter

Gram - spiral -motile by spiral motility-humans are reservoir

H. pylori is the most significant-causes gastric ulcers

Acquired throughout life-more frequent in adults than children

Urease is very important-allows localized pH change

Penetrates mucosal cells into epithelium

Tissue damage is caused by LPS, urease products, and a cytotoxin that damages epithelium

Highly successful treatment with antibiotics