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Misc. Enterics and Gram- bacteria

Misc. Enterics and Gram- bacteria. Klebsiella. K. pneumoniae is most common pathogen Pneumonia ( nosocomial ) or UTI (makes urease ) Often associated with patient intubation Uses type 1 and type 3 (MRK) fimbriae Environmental organism Associated with plant roots, fixes nitrogen.

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Misc. Enterics and Gram- bacteria

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  1. Misc. Enterics and Gram- bacteria

  2. Klebsiella K. pneumoniaeis most common pathogen Pneumonia (nosocomial) or UTI (makes urease) Often associated with patient intubation Uses type 1 and type 3 (MRK) fimbriae Environmental organism Associated with plant roots, fixes nitrogen

  3. Serratia • S. marcescensis most common human pathogen • Opportunistic pathogen • Death knell of nosocomial pneumonia • Produces proteases that degrade host tissue • Hydrophobic cell surface adheres to medical plastics • Causes corneal ulcers in contact wearers • Often produces pink/orange pigment called prodigin • Type 1 and type 3 fimbriae probably evolved from common Serratiafimbriae

  4. Proteus • P. mirabilis is most common pathogen • Primarily urinary tract infections • Proteus swarms-highly mobile • If you inoculate small point on agar plate proteus will swim out to form a large ring • Very strong urease producer-renal calculi

  5. Campylobacter Gram - bacterium grows at 42°C in High CO2, low oxygen C. jejuniis most common human pathogen-gastroenteritis, bloody diarrhea can last for 1 week Causes tissue damage in jejunum Virulence factors include LPS, adhesins and flagella catalase and oxidase Can spread, but is self-limiting C. fetus expresses S protein that prevents complement activity and phagocytosis Disseminates to blood and other systems readily Immunocompromised patients are most affected

  6. Helicobacter Gram - spiral -motile by spiral motility-humans are reservoir H. pylori is the most significant-causes gastric ulcers Acquired throughout life-more frequent in adults than children Urease is very important-allows localized pH change Penetrates mucosal cells into epithelium Tissue damage is caused by LPS, urease products, and a cytotoxin that damages epithelium Highly successful treatment with antibiotics

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