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Understanding Amidophosphoribosyltransferase N-terminal Nucleophile Glnase: A Structural Model

Explore a detailed model of the active site of Amidophosphoribosyltransferase N-terminal Nucleophile Glnase, illustrating interactions with substrates NH3 and H3N.CO2-, and the role of feedback inhibition by ADP and GMP.

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Understanding Amidophosphoribosyltransferase N-terminal Nucleophile Glnase: A Structural Model

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  1. O O O OH O OH OH OH OH A model of the active site of Amidophosphoribosyltransferase N-terminal nucleophile Glnase Glnase Glnase + H3N + H3N COO- O O COO- H S S H2N H2N+ O O NH3 H2N H G PRTase PRTase PRTase Pi Pi Pi O- O- O O P P O O O O O O H O PRTase P P O P O- O O- O- O- O- O- O A O P “A” Site O OH OH “A” Site “A” Site Before reaction (substrates bound) NH3 Channeling Feedback Inhibition by ADP+ GMP

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