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a. c. b. a. c. NLRP-3. IL-1 β. ASC. TNF- α. TIMP-1. MMP-9. A. 5.0. 4.5. 4.0. 3.5. 3.0. relative mRNA expression. 2.5. 2.0. 1.5. 1.0. 0.5. 0. wild type. Atp7b -/-. B. wild type. Atp7b -/-. kD. 10. 13. 15. 23. 11. 11. 24. 24. age (months). 55. TNF-R1.

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  1. a c b a c NLRP-3 IL-1β ASC TNF-α TIMP-1 MMP-9 A 5.0 4.5 4.0 3.5 3.0 relative mRNA expression 2.5 2.0 1.5 1.0 0.5 0 wild type Atp7b-/- B wild type Atp7b-/- kD 10 13 15 23 11 11 24 24 age (months) 55 TNF-R1 α-SMA 43 25 LCN2 TIMP-1 23 β-actin 42 Suppl. Figure 1

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