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50. *. 40. 30. Percent Reduction in RCR From basal rate. 20. 10. 0. Control + Ca 2+. E 2 + Ca 2+. A. Mito. GlutMal. Ca 2+. ADP. 250. Control. 225. Ca 2+ 100 µM. 200. State 4 +Ca 2+ = -4.82+/-2.42 -Ca 2+ = -4.82+/-2.1. O 2 (nmol). 175. State3 +Ca 2+ = -10.05+/-5.91

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  1. 50 * 40 30 Percent Reduction in RCR From basal rate 20 10 0 Control + Ca2+ E2 + Ca2+ A Mito GlutMal Ca2+ ADP 250 Control 225 Ca2+ 100 µM 200 State 4 +Ca2+= -4.82+/-2.42 -Ca2+= -4.82+/-2.1 O2 (nmol) 175 State3 +Ca2+ = -10.05+/-5.91 -Ca2+= -18.83+/-8.22 (p<0.05; n=7) RCR +Ca2+ = 2.08+/-0.57 (46%-) -Ca2+= 3.90+/-0.78 (p<0.05; n=7) 150 125 100 0 1 2 3 4 5 6 7 8 9 Time (min) B Mito GlutMal Ca2+ ADP 275 250 Control + Ca2+ E2 + Ca2+ 225 State 4 C= -4.82+/-2.42 E2= -5.11+/-2.65 O2 (nmol) 200 State3 C= -10.05+/-5.91 E2= -17.59+/-6.73 (p<0.05; n=7) 175 RCR C= 2.08+/-0.57 E2= 3.44+/-0.78 (21%+) (p<0.05; n=7) 150 125 0 1 2 3 4 5 6 7 8 9 Time (min) C

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