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Kharkiv National Medical University Medical and bioorganic chemistry department

Kharkiv National Medical University Medical and bioorganic chemistry department. Lecture Fundamentals of titrimetric analysis. Outline. 1. History of development of titrimetric analysis 2. The main concepts of titrimetric analysis 3. Equipment for titrimetric analysis

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Kharkiv National Medical University Medical and bioorganic chemistry department

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  1. Kharkiv National Medical UniversityMedical and bioorganic chemistry department Lecture Fundamentals of titrimetric analysis

  2. Outline 1. History of development of titrimetric analysis 2. The main concepts of titrimetric analysis 3. Equipment for titrimetric analysis 4. Requirements that apply to the standard substance 5. Requirements that apply to the reaction in titration 6. Classification of titrimetric methods 7. Types of titrimetric determinations 8. Examples of calculations in titrimetric analysis

  3. Actuality of the theme: Titrimetric (volumetric) analysis is one of the methods  of quantitative analysis in analytical chemistry which is widely used in medical-biological and sanitary-hygienic investigations for analysis of biological liquids, drinking and tap water and other objects. • This method is universal, it has sufficiently high accuracy, relatively simple and needn’t difficult measuring equipment.

  4. History of development of titrimetry Mikhail Lomonosov is originator of quantitative analysis François Descroizilinvented burettes and pipettes, used volumetric flasks Robert Boyle studied neutralization of acids with bases in the presence of indicators K.F. Mohr summarize data and published (in 1853) first guidance on titrimetric methods. J. L. Gay-Lussac . known as an author of “The Law of Combining Volumes.”

  5. Equipment for titrimetric analysis Erlenmeyer flask or conical flask BALANCE Technical Analytical

  6. Volumetric flasks Volumetric flask is a piece of laboratory glassware, a type of laboratory flask, calibrated to contain a precise volume at a particular temperature. Volumetric flasks are used for precise dilutions and preparation of standard solutions. .

  7. Equipment for titrimetric analysis Burettes Pipettes Graduated cylinders

  8. When you burette is filled, with no air bubbles, you must level of the liquid to exactly the zero mark. Read the bottom of the meniscus. Be sure your eye is at the level of meniscus, not above or below

  9. Typical instrumentation for performing an automatic titration.

  10. Classification of titirimetric (volumetric) methods

  11. pH ranges for the most widely used indicators

  12. HCl + NaOH NaCl + H2O Strong Acid-Base Titration Curve Atitration curve is a plot of pH vs. the amount of titrant added.

  13. Weak Acid-Strong Base Titration Curve C3H8COOH + NaOH ↔ C3H8COONa + H2O

  14. Weak Base-Strong Acid Titration Curve NH4OH + HCl ↔ NH4Cl + H2O

  15. Types of titrimetric determinations Titration can be: • direct titration • back-titration (on residue) • substitute-titration (displacement titration) • revertive titration Direct titration – titrant is added to an analyte solution and it reacts with determined substance. А + Т = product

  16. Example: 8 ml of NaOH solution were used to titrate 10 ml of Н2С2О42Н2О with С(1/2Н2С2О42Н2О) = 0,05 mol/l. Calculate C (NaOH) and T (NaOH). Solution: According to the law of equivalents С(E)(Н2С2О4 . 2Н2О)×V(Н2С2О4 . 2Н2О)= CE(NaOH)×V(NaOH)then CE(NaOH) = =

  17. Thank you for your attention!

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