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Cellular and Extracellular Lesions II: Hepatic Steatosis

Explore hepatic steatosis, a condition characterized by fatty liver, through detailed images and explanations of causes such as diabetes, malnutrition, and toxic substances like alcohol. Learn about localized hemosiderosis and jaundice manifestations. Delve into hyalinosis of afferent glomerular arteriole and amyloidosis in renal pathology.

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Cellular and Extracellular Lesions II: Hepatic Steatosis

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  1. Cellular and extra cellular lesions II

  2. Steatosis (fatty change)From: Stevens A. J Lowe J. Pathology. Mosby 1995 Fig.4.1 Fig. 4.1 Causes of fatty change: diabete, malnutrition, toxic substances (alcohol), chronic hypoxia, over-feeding, etc. Cell poison (alcohol)=>reduced cell enzyme activity=>inability to metabolise fat=>fat cell accumulation

  3. Hepatic steatosis Fig.4.2 Fig. 4.2. Fatty liver is enlarged and yellow

  4. Hepatic steatosisFrom cases of the Pathology Department - U.M.F. “Gr. T. Popa” Iasi Fig.4.3

  5. Fig.4.4 Fig.4.3-4. Fatty liver. Small and large unstained fat intracellular vacuoles with clear borders.

  6. Hepatic steatosisFrom cases of the Pathology Department - U.M.F. “Gr. T. Popa” Iasi Fig. 4.5. Fig. 5. Fatty liver – HE: small and large clear vacuoles.

  7. Fig. 4.6. Fig. 6. Black Sudan: intracellular lipid deposits are black stained

  8. Localized hemosiderosisFrom cases of the Pathology Department - U.M.F. “Gr. T. Popa” Iasi Fig.4.7 Fig.7 HE-hemosiderin appears as a yellow brown granular pigment

  9. Fig. 4.8. Fig.8. In Perls reaction, hemosiderin is blue in color.

  10. Jaundice From: Stevens A. J Lowe J. Pathology. Mosby 1995 Fig. 4.9. Fig. 9. Icterus: yelow color of skin and sclerae.

  11. Fig. 4.10. Fig. 10. In icterus, liver is greenish-yellow.

  12. Jaundice From cases of the Pathology Department - U.M.F. “Gr. T. Popa” Iasi Fig. 4.11.

  13. Fig. 4.12. Fig. 11-12. In hepatic icterus: (a) intrahepatocyte granular pigment - hepatocyte cytoplasm contains bilirubin as small greenish-brown granules. (b) billiary cylinder (billiary thrombi) - small biliary channels are distended through greenish-brown pigment; is a characteristic feature in cholestatic jaundice.

  14. Hyalinosis of afferent glomerular arterioleFrom: Stevens A. J Lowe J. Pathology. Mosby 199 Fig. 4.13.

  15. Fig. 4.14. From cases of the Pathology Department - U.M.F. “Gr. T. Popa” Iasi Fig. 13-14. Afferent arteriolewall hyalinosis, partial or total hyalinosis of glomeruli, and dilated renaltubules with hyaline plugs (thyroidization).

  16. AmyloidosisFrom: Stevens A. J Lowe J. Pathology. Mosby 1995 Fig. 4.15.

  17. Fig. 4.16.

  18. Histology of renal amyloidosisFrom: Stevens A. J Lowe J. Pathology. Mosby 1995 Fig. 4.17.

  19. Fig. 4.18.

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