Basics of Pharmacokinetics and Pharmacodynamics in Physiological Psychology

1. Proseminar in Physiological Psychology (PSY 627) Chapter 4

2. Pharmacokinetics a. route of administration b. absorption and elimination Pharmacodynamics a. dose-effect curve b. therapeutic index c. ligand binding d. agonist vs. antagonist e. neurotransmitter systems

3. Pharmacokinetics a. route of administration b. absorption and elimination Pharmacodynamics a. dose-effect curve b. therapeutic index c. ligand binding d. agonist vs. antagonist e. neurotransmitter systems

4. Routes of Administration a. oral easy self-administration prolonged effect stomach distress some drugs not orally effective b.topical applied only to needed area poor absorption c. rectal infants and unconscious adults variable absorption d.inhalation rapid onset/offset irritation e. injection rapid onset good control of dosage requires sterile conditions

5. Injection Route a. Intravenous (i.v.)- into vein b. Subcutaneous (s.c.)- under skin c. Intraperitoneal (i.p.)- into peritoneal cavity d. Intracerebroventricular (i.c.v.)- into cerebral ventricle e. Intrathecal- into spinal fluid f. Epidural- into space that surrounds the dura of spinal cord g. Intramuscular (i.m.)- into muscle

7. Pharmacokinetics a. route of administration b. absorption and elimination Pharmacodynamics a. dose-effect curve b. therapeutic index c. ligand binding d. agonist vs. antagonist e. neurotransmitter systems

9. Pharmacokinetics a. route of administration b. absorption and elimination Pharmacodynamics a. dose-effect curve b. therapeutic index c. ligand binding d. agonist vs. antagonist e. neurotransmitter systems

11. Comparing Dose-Effect Curves Drug A Drug B % of Maximal Effect Drug C [Drug]

12. Pharmacokinetics a. route of administration b. absorption and elimination Pharmacodynamics a. dose-effect curve b. therapeutic index c. ligand binding d. agonist vs. antagonist e. neurotransmitter systems

14. Pharmacokinetics a. route of administration b. absorption and elimination Pharmacodynamics a. dose-effect curve b. therapeutic index c. ligand binding d. agonist vs. antagonist e. neurotransmitter systems

15. Saturation

16. Scatchard plot

17. RECEPTOR-LIGAND BINDING • Must be saturable • Must be reversible • Must be specific • If it is a receptor, there must be a biological effect

18. Pharmacokinetics a. route of administration b. absorption and elimination Pharmacodynamics a. dose-effect curve b. therapeutic index c. ligand binding d. agonist vs. antagonist e. neurotransmitter systems

19. % Maximum Effect [Drug]

21. Agonist Agonist + competitive antagonist % of Maximal Effect Agonist + non-competitive antagonist [Drug]

22. Pharmacokinetics a. route of administration b. absorption and elimination Pharmacodynamics a. dose-effect curve b. therapeutic index c. ligand binding d. agonist vs. antagonist e. neurotransmitter systems

23. NEUROTRANSMITTER CRITERIA • Must be localized in neuron • Must be released with stimulation • Must be mimicked with exogenous application • Must be pharmacologically active at receptor