1 / 34

Critical Reading of Medical Articles

Critical Reading of Medical Articles. Introduction to Primary Care a course of the Center of Post Graduate Studies i n FM. PO Box 27121 – Riyadh 11417 Tel: 4912326 – Fax: 4970847. Aim: knowledge on the principles of critical reading (appraisal) of medical articles.

joey
Download Presentation

Critical Reading of Medical Articles

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript


  1. Critical Reading of Medical Articles Introduction to Primary Care a course of the Center of Post Graduate Studies in FM PO Box 27121 – Riyadh 11417 Tel: 4912326 – Fax: 4970847

  2. Aim: knowledge on the principles of critical reading (appraisal) of medical articles. Objectives: at the end of this presentation, the participants should be able; • to assess the quality of the article to determine if the conclusions are valid • to explain how to start reading • to explain the results of an article and their relevance to your practice.

  3. What is critical reading ? • Theassessment of evidence by systematically reviewing its relevance, validity and results to specific situations. - Chambers, R. (1998). It is an essential skill for evidence-based medicine.

  4. Why read medical articles critically? • Convert our information needs into answerable questions. • Track down, with maximum efficiency, the best evidence with which to answer these questions. • Appraise the evidence critically, assess its validity and usefulness (clinical applicability).

  5. 4.To implement the results of this appraisal into our clinical practice. 5.To evaluate our performance. Published research is not always reliable or relevant.

  6. Difficulties with Critical Appraisal • Can be time consuming initially • Doesn’t provide an “easy” answer • It could show a lack of good evidence in a particular topic

  7. Key Steps to Effective Critical Appraisal 1. Are the results valid? 2. What are the results? 3. How will these results be relevant to the patient?

  8. Basic elements of clinical decision making

  9. Steps to EBM 1. Formulate a clear, focused clinical question 2. PICO model 3. Search the literature for the best external evidence 4. Critically appraise the evidence for its validity and usefulness 5. Implement the useful evidence in clinical practice 6. Evaluate the results

  10. Different types of question requiredifferent study designs

  11. Study designs for Question Types

  12. PICO Structure Patients P Intervention I Comparison C Outcome O

  13. Clinical Scenario What therapeutic agents can be used for rate control of atrial fibrillation (AF) in a patient with congestive heart failure (CHF)?

  14. Starting Point Break the question into the following components: Population: Patients with atrial fibrillation AND congestive heart failure Intervention: Rate control Comparison: N/A Outcome: Mortality, effectiveness of rate control

  15. MeSH • Medline Subject Headings (MeSH terms) are assigned to each article. • Provide consistent way to retrieve articles • MeSH “a controlled vocabulary organised in a tree structure” • index = like chapter headings in a text book • Major Subject Headings (eg Leg) • Subject Headings (eg knee) • Subheadings (eg cruciate ligament)

  16. How can we do Critical Appraisal? • Use common sense • Use simple checklists • Use different checklists depending on the different types of studies (i.e., RCTS, systematic reviews etc) • Checklists help you focus on the important parts of the article

  17. Research Methodology • Who were the participants of the study? • How were they recruited? • Was there bias in the recruiting methods? • How was the data collected? • What statistical tests were used? • Where the data collection methods accurate?

  18. Critical appraisal questions • What is the paper about? • Why was the study done? • What type of study was done? • Was it primary research (experiment, RCT, cohort, case-control, cross-sectional, longitudinal, case report/series)?

  19. Critical appraisal questions • Was it secondary research (overview, systematic review, meta-analysis, decision analysis, guidelines development, economic analysis)? • Was the design appropriate (for study on treatment, diagnosis, screening, prognosis, or causation)? • Was the study ethical?

  20. What makes studies reliable? • First look for biases in the study. • Bias can be defined as ‘the systematic deviation of the results of a study from the truth because of the way it has been conducted, analysed or reported’.

  21. A study which is sufficiently free from bias is said to have internal validity • Different methods of collecting evidence are graded as to their relative levels of validity. • To minimise bias, double-blind randomised controlled trials are the best for evidence.

  22. A system for reading an original article • First, “scan” the article: -A brief review of the length, headings, key and concluding sentences of each section is worthwhile. -How much time it will take to read the article carefully -Provoke questions or the need for clarification which will direct your focus during a second detailed reading.

  23. In general, original articles will comprise: • A title • An abstract or summary • A methods (and materials) section • Results • Discussion • References

  24. A title • A title will normally contain three elements : -setting (types of patients and circumstances under which the study is performed) • intervention (in prospective randomised controlled trials) or study factor • outcome measure • E.g. Effect of carbon dioxide neumoperitoneum [ intervention] on development of atlectasis • [ outcome] during anaesthesia [setting].

  25. AIM Research Question? Well defined? Worthwhile? (Intro) Appropriate? Tested properly by method? • BACKGROUND INFORMATION (Intro) Author, Journal, Type of Study. • Strengths/weaknesses • SETTING Primary/secondary care? Type of practice? • (Method) Strengths/weaknesses C) SAMPLE Large enough? Comparable with normal (Method) population? Randomly selected? Biased? Inclusion/exclusion criteria?

  26. CONTROLS Used or not? How were they selected? • (Method) Matched for all relevant factors? • Any confounding factors? • DESIGN Appropriate? Retrospective or prospective? (Method) Quantitative/qualitative? Observational/ Experimental? Double blind? Placebo controlled? • DATA Were questionnaires piloted? Response rate? (Method/results) Outcome measures defined?Was measurement validated/reliable? Understandable clear data represented accurately? Are statistics appropriate?

  27. ETHICAL Local Ethics Committee Approval? • Pt consent? • EVALUATION Summary of findings. Study strength and (Discussion) limitations. Comparison with existing literature. Answer research question? • EFFECTIVE Are conclusions made in discussion justified (Discussion) by results? Clinically significant? Clinically relevant? Clinically applicable?

  28. Stats…..! • Means to compare samples of populations • P values : The probability that any particular out come would have arisen by chance p < 0.05 = statistically significant • Confidence Intervals : Estimated range that is likely to include the true value • Numbers Needed to Treat : Estimated number of patients that need to be treated with a new treatment for one additional patient to benefit

  29. Predictive Value of tests Confidence Intervals Relative Risk Reduction Intention to treat P Value Relative Risk Absolute Risk Difference Sensitivity Absolute Risk Reduction Absolute Benefit Increase Specificity Likelihood Ratio Numbers Needed to Treat (NNT) Odds Ratio

  30. READER acronym to aid critical readingMacAuley. BJGP 1994; 44,83-85 • Relevance - reader’s context • Education - behaviour modification • Applicability - readers own practice • Discrimination - validity, quality • Evaluation - scoring system • Reaction - what to do with the paper..!

More Related