Genefron Personalized Medicine Diagnostic July 2013. Because Response to Interferon is Personal. Genefron LTD Team. Genefron Ltd. is an Israeli based, privately held company company that specializes in the development of in-vitro diagnostic kits for personalized medicine. Our Team:
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Personalized Medicine Diagnostic
Because Response to Interferon is Personal
Direct Antiviral Agents
INF induced genes
personal gene expression
Innate immune response:
RNAase, Ubiquitin etc
Proteins – virus degradation
1.5% of WW population is infected with HCV.
Currently only about 50% of the Caucasians, 30% of Asians and 80% of the Afro-Americans a HCV patients are non responders to the PEGylatedIFNa treatment.
Non-responders and relapsed patients report severe adverse effectsand incur long and expensive treatments with minimal clinical results.
Genefron’ s qRT PCR Diagnostic kit, IFR10, from liver tissue or blood samples measuring INF personal gene expression (PGE) signature can identify responders /non responders with ~ 96% accuracy will have an immediate and profound influence on MDs' decision of a specific patient optimal treatment, feasible outcome and cost.
Top 10 genes
Example 1: We have used our algorithm on published RT PCR data (Dill et. al. Lausanne SW, 2011) which included 27 patients (X axis), RT-PCR – liver tissue, HCV Type 1 prior to PEG INF treatment. The patients presents various PGE signature (Y axis). The results identified 2 major groups responders (red) and non responders (blue) in 96% accuracy.
Example 1: Dill et.al. Lausanne SW, 2011. data after analysis ROC curve
Saving of $16.5M
MS patients- the graph represent 15 patients (X axis) PGE Signature Genes (Y axis) before and 24h after IFN-b treatment. Notice the expression “shutdown” in the non responders: