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  1. Figure 1 RYR1 Ca2+ channel domain 1000 2000 3000 4000 5000 COOH NH2 DHPR IP3R E4032 IP3-binding domain Ca2+ channel domain 1000 2000 NH2 COOH SII SI E2100 SII- Type 1 Type 2 Type 3

  2. Figure 2 A 1000 2000 IP3-binding domain Ca2+ channel domain NH2 COOH B W1577A IP3-binding domain 1 600 1499 1649 [32] [99] [57] [58] and data not shown [18]