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Coccidiosis Poultry Vaccines

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  1. Coccidiosis Poultry Vaccines • Akzo Nobel N.V. (Intervet) • British Technology Group U.S.A., Inc. • USDA • Enzon • Hoffmann-La Roche • Solvay & Cie, S.A. • Pfizer

  2. Coccidiosis Poultry Vaccines • Akzo Nobel N.V. (Intervet) • British Technology Group U.S.A., Inc. • USDA • Enzon • Hoffmann-La Roche • Solvay & Cie, S.A. • Pfizer

  3. Eimeria in Poultry • Eimeria tenella • Eimeria necatrix • Eimeria acervulina • Eimeria maxima • Eimeria brunetti • Eimeria mivati • Eimeria mitus • Eimeria meleagrimitis • Eimeria adenoides

  4. Coccidiosis Poultry Vaccines • Akzo Nobel N.V. (Intervet) • British Technology Group U.S.A., Inc. • USDA • Enzon • Hoffmann-La Roche • Solvay & Cie, S.A. • Pfizer

  5. Eimeria in Poultry • Eimeria tenella • Eimeria necatrix • Eimeria acervulina • Eimeria maxima • Eimeria brunetti • Eimeria mivati • Eimeria mitus • Eimeria meleagrimitis • Eimeria adenoides

  6. Sporozoite proteins Merozoite proteins E. acervulina E. tenella 200 kD 100 kD 50 kD 20 kD US5843722 US5814320 US5795741 US5792644 US5789233 US5783197 US5780289 US5677438 US5670362 US5614195 US5602033 Eimeria vaccines Akzo Nobel N.V.

  7. Life cycle of coccidia

  8. Sporozoite of Eimeria ssp.

  9. Invasion des Sporozoiten

  10. Sporogonie und Merogonie

  11. Eimeria tenella

  12. Economic Impact of coccidiosis • US 300 Mio $ loss/year • (3 billion broilers estimate (6.741 in 1997) • US 100 Mio to 150 Mio/year • NovoPlant 150 to 250 Mio $ USA • 15-30 Mio DM in BRD 1997 bei 750 Mio Produktion • 160-320 Mio DM in EU 1996 • 1.0 to 2.0 cents/ kg • 13 Mio Guilders in NL

  13. Effectiveness of Vaccination against E. tenella 4 week old birds, 2.4 mg antigen, 75,000 oocysts, US Patent 5279960

  14. Recombinant anticoccidial vaccine(US5635181 BTG) Challenge with 90000 oocysts of E.tenella, E.mitis, E.acervulina, E.maxima, E. brunetti * 10 6 oocysts / g feces

  15. Protection against E. acervulina infection US5783197 Vermeulen et al.

  16. MABs against sporozoite antigens can reduce rate of E.tenella infection

  17. Methods of Vaccination against Eimeria • Fowl pox virus • Yeast surface protein • Bacterial surface protein • Injection • Drinking water • Feed US4710377 Schenkel et al.

  18. Monoclonal Antibodies used for antigen screening