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Erythrocyte Leukocyte Platelet Plasma and serum Stem cell theory. Hemoglobin Hematocrit Anticoagulant EDTA. Week 3: Hematopoiesis. Blood. Circulate O 2 , nutrients, heat, etc. Erythrocyte Leukocyte Platelet (thrombocyte) Plasma and serum. Inside of a blood vessel SEM x 2,500.

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week 3 hematopoiesis
Erythrocyte

Leukocyte

Platelet

Plasma and serum

Stem cell theory

Hemoglobin

Hematocrit

Anticoagulant

EDTA

Week 3: Hematopoiesis
blood
Blood
  • Circulate O2, nutrients, heat, etc.
  • Erythrocyte
  • Leukocyte
  • Platelet (thrombocyte)
  • Plasma and serum
anticoagulant
Anticoagulant
  • Chelate Ca++ ions
    • EDTA
    • Citrate
  • Inhibit clotting enzyme
    • Heparin
  • Inhibit glycolysis
    • Fluoride
stem cell theory
Stem Cell Theory
  • Pleuripotential stem cell
  • Blast cells
  • Differentiation and maturation
  • Release into circulation
recycling old cells
Recycling Old Cells
  • RBCs have 120-day life span
  • Reticulo-endothelial system removes old and damaged cells
  • Hemoglobin is made of Fe++, porphyrin ring, and globin chains
  • Fe++ and globin chains (amino acids) are recycled, but porphyrin ring is eliminated
red cell production
Red Cell Production
  • Oxygen tension
  • Level of erythropoietin EPO
  • Need for more red cells (during growth, recovering from anemia)
hemoglobin
Hemoglobin
  • Normal adult Hb A
    • 2  globin chains
    • 2 b globin chains
    • Heme: porphyrin plus Fe++
  • Minor Hb’s
    • 22: Hb A2
    • a2g2: Hb F
kinds of hemoglobin
Kinds of Hemoglobin
  • Oxyhemoglobin: O2
  • Reduced (deoxy-) hemoglobin: no O2
  • Methemoglobin: oxidized
  • Carboxyhemoglobin: 218 times affinity to CO than O2
  • Sulfhemoglobin: sulfa drugs
hb problems
Hb Problems
  • Heme production problem: porphyria
  • Fe++ problems: IDA, hemochromatosis
  • Globin problem: sickle cell disease, thalassemia
hb test
Hb Test
  • Reference ranges:
    • Male 14.0 - 17.0 g%
    • Female 12.0 - 15.0 g%
  • Cyanomethemoglobin method
    • Drabkin’s reagent - ferricyanide
    • Coulter Hemoglobinometer
hematocrit
Hematocrit
  • Reference ranges
    • Male 42 - 52%
    • Female 36 - 46%
  • Packed cell volume
  • Modern instruments calculate Hct from RBC and average cell size
correlation
Correlation
  • Internal QC

Hb x 3 ≈ Hct ± 3