Microbial Risk Assessment Frameworks, Principles, and Approaches. Rebecca Parkin, PhD, MPH Department of Environmental and Occupational Health Center for Risk Science and Public Health, School of Public Health and Health Services The George Washington University Medical Center [email protected]
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Microbial Risk AssessmentFrameworks, Principles, and Approaches
Rebecca Parkin, PhD, MPH
Department of Environmental and Occupational Health
Center for Risk Science and Public Health, School of Public Health and Health Services
The George Washington University Medical Center
Food (fresh and processed)
Modified organisms (contamination, cleanup)
Estimate magnitude of disease burdens
Identify high risk sub-populations
Dialysis, cancer patients
Guide policy decisionsPurposes of MRA
ILSI/EPA Framework pathogens
Ordered, iterative process pathogens
Complete source-response pathway assessments
Use field & clinical measurements
Accommodate different pathogens, contexts, scenarios, dynamics
Assumptions, data limitations
Open, transparent processesGuiding Concepts
Problem formulation pathogens
What is THE problem?
How can it be modeled?
For what purpose?
Comprehensiveness of approach
Analytic plan (sources & use of data)
Linkages of dynamic ecological & population scale disease models
Compatibility of model structure & components with complexity of the problem
Evaluation of the model
Analysis of uncertainty & variability
Explicit identification of assumptions
Use of probabilistic methodsKey Challenges