1 / 5

CURRENT-OASIS 7

CURRENT-OASIS 7. Objective: To assess the effect of various clopidogrel and aspirin regimens on major CV events and ST in ACS patients undergoing PCI. Study: Multicenter, randomized trial. 2 x 2 factorial design.

janus
Download Presentation

CURRENT-OASIS 7

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. CURRENT-OASIS 7 Objective: To assess the effect of various clopidogrel and aspirin regimens on major CV events and ST in ACS patients undergoing PCI. Study: Multicenter, randomized trial. 2 x 2 factorial design. Population: ACS patients (STEMI, NSTEMI, unstable angina with ST depression). Endpoint: Composite of CV death, MI or stroke.

  2. High dose aspirin N=6253 CAG PCI ≤ 72h Double + high N=4298 Double dose clopidogrel N=12520 Double + Low N=4262 Low dose aspirin N=6267 Randomized N=25086 High dose aspirin N=6254 Standard + High N=4326 Standard dose clopidogrel N=12566 Low dose aspirin N=6312 Standard + Low N=4376 No PCI N=7823 CURRENT-OASIS 7

  3. CURRENT-OASIS 7 Event rate at 30 days (%) p=0.039 p=0.71 p=0.018 p<0.001 p=0.009

  4. CURRENT-OASIS 7 p=0.76 p=0.35 p=0.80 p=0.62 p=0.22

  5. CURRENT-OASIS 7 Conclusion: In patients undergoing PCI for ACS a 7 day double dose clopidogrelregimen was associated with a reduction in CV events and ST. No difference was found between high and low dose aspirin. Mehta et al. Lancet 2010;376:1233-43

More Related