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. Parametric Sensitivity Analysis. Parametric sensitivity analysis investigates the relationship between the variables and parameters in a biochemical network.. Variables1. Concentrations2. Pathway fluxes3. Dynamic response4. Growth rate5. ..... Parameters1. Enzyme activity levels2. Kinetics constants3. Decay rates4. Boundary conditions5. .....

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## Parametric Sensitivity Analysis

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**3. **Parametric Sensitivity Analysis:Example

**7. **Sensitivity Analysis: General Computation

**8. **Application: unregulated chain

**10. **Application: product feedback

**12. **Metabolic Control Analysis (MCA)

**13. **Utility of MCA

**14. **Utility of MCA

**15. **Utility of MCA

**17. **Time-Varying Sensitivities

**18. **Example

**19. **Application to Phototransduction Pathway

**20. **Global Sensitivity Analysis Addresses system behaviour over a wide range of parameter values
Primarily statistical tools: efficient sampling methods
Provides a broader view of behaviour, but…
Results often difficult to interpret

**21. **Applications of Sensitivity Analysis Predicting the effect of interventions
Drug development

**22. **Applications of Sensitivity Analysis Predicting the effect of interventions
Drug development
Medicine

**23. **Applications of Sensitivity Analysis Predicting the effect of interventions
Drug development
Medicine
Metabolic engineering

**24. **Applications of Sensitivity Analysis Predicting the effect of interventions
Drug development
Medicine
Metabolic engineering
Model construction and analysis
Identifying key variables

**25. **Applications of Sensitivity Analysis Predicting the effect of interventions
Drug development
Medicine
Metabolic engineering
Model construction and analysis
Identifying key variables
Model calibration

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