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NIH Nutrition Research

NIH Nutrition Research. Dr. Griffin P. Rodgers Director National Institute of Diabetes and Digestive and Kidney Diseases, NIH April 5, 2008 American Society for Nutrition, Experimental Biology 2008. NIH. $1B. (90%). Other DHHS. Other Non-DHHS. USDA. $13M*. $11M*. $97M. (1%). (1%).

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NIH Nutrition Research

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  1. NIH Nutrition Research Dr. Griffin P. Rodgers Director National Institute of Diabetes and Digestive and Kidney Diseases, NIH April 5, 2008American Society for Nutrition, Experimental Biology 2008

  2. NIH $1B (90%) Other DHHS Other Non-DHHS USDA $13M* $11M* $97M (1%) (1%) (8%) Federal Expenditures in Support of Human Nutrition Research and Training, FY 2005 * Estimate Source: Human Nutrition Research and Information Management (HNRIM) System database

  3. 4,500 1,200 4,000 1,000 3,500 800 3,000 600 2,500 400 2,000 97 98 99 00 01 02 03 04 05 06 97 98 99 00 01 02 03 04 05 06 NIH Nutrition Research and Training Support (FY 1997-2006) Expenditures(Dollars in millions) Number of Projects Fiscal Year Fiscal Year Source: Human Nutrition Research and Information Management (HNRIM) System database

  4. NIMH 2% Other ICs (15) 9% NIEHS 3% NCCAM5% NIDDK26% NCRR5% NIA5% NICHD5% NCI21% NHLBI19% NIH Nutrition Research and Training Support FY 2006(NIH Total ~$1 billion) Source: Human Nutrition Research and Information Management (HNRIM) System database

  5. NIH Division of Nutrition Research Coordination (DNRC) • Advises NIH Director and others on nutrition research issues and works with the NIH organizational components to coordinate nutrition research and research training initiatives. • Coordination of nutrition research and nutrition policy-related activities by the DNRC occurs at 3 major organizational levels: (1) trans-NIH activities; (2) interagency activities at the Department of Health and Human Services (DHHS) level (3) interagency activities at the Federal level.

  6. Additional Coordination of Trans-NIH Nutrition Research Activities NIH Nutrition Coordinating Committee (NCC) • Established in 1975 in the Office of the Director, NIH • Operates as NIH-wide forum to review, stimulate, and encourage the support of nutrition research and training to better define the role of nutrition in the promotion and maintenance of health and in the prevention and treatment of disease. Functions and responsibilities of the NCC are now encompassed within the framework of the DNRC. • Currently consists of representatives from 27 institutes & Centers and of several Offices at the NIH. Additionally, all other agencies of the DHHS, as well as other Departments (USDA, DOD, DOEd) have liaison representatives to the committee.

  7. Sources of Information on Federally Funded Nutrition Research • Human Nutrition Research Information Management (HNRIM) System: Maintained by HNRIM staff, NIH DNRC • Searchable database of nutrition research and research training activities supported by the federal government • Operational since 1985; Updated yearly • For more information: http://hnrim.nih.gov/ • Other databases: • CRISP: http://crisp.cit.nih.gov/ • CARDS: http://ods.od.nih.gov/Research/CARDS_Database.aspx/

  8. NIH Nutrition Research Areas—Examples • Cancer and Nutrition • Obesity, Anorexia, and Appetite • Cardiovascular Disease and Nutrition • Genetics and Nutrition • Prevention and Nutrition • Clinical Trials, Nutrition • Lipids (Fats and Oils) • Vitamins • Dietary Supplements (Nutrient ingredients; • Botanical and other non-nutrient ingredients) Source: Human Nutrition Research and Information Management (HNRIM) System database

  9. 300 1,200 250 1,000 200 150 800 100 600 97 98 99 00 01 02 03 04 05 06 50 97 97 99 00 01 02 03 04 05 06 NIDDK Nutrition Research and Training Support (FY 1997-2006) Expenditures(Dollars in millions) Number of Projects Fiscal Year Fiscal Year Source: Human Nutrition Research and Information Management (HNRIM) System database

  10. NIDDK’s Division of Digestive Diseases and Nutrition (DDN): Nutrition-Related Programs INVESTIGATOR INITIATED: • Genetics and Genomics of Nutrition and Obesity • Clinical Obesity and Nutrition • Nutritional Epidemiology & Data Systems • Nutrient Metabolism • Childhood Obesity • Obesity Prevention & Treatment • Obesity & Eating Disorders INITIATIVE SUPPORT: • Look AHEAD Clinical Trial of long-term decreased caloric intake and exercise to achieve and maintain weight loss • Longitudinal Assessment of Bariatric Surgery • Nonalcoholic Steatohepatitis Network Trials of Vitamin E or insulin-sensitizing drugs in adults and children • Clinical Nutrition Research Units • Obesity/Nutrition Research Centers

  11. NIDDK’s Division of Diabetes, Endocrinology, and Metabolic Diseases: Nutrition-Related Programs INVESTIGATOR INITIATED: • Role of nutrition in the treatment of cystic fibrosis—newborn screening for early diagnosis and pancreatic enzyme replacement to enhance dietary absorption, and behavioral interventions have been shown to prevent growth failure in kids. • Nuclear receptor research—Understanding mechanism of action of vitamin D; role of vitamin D in bone health. INITIATIVE SUPPORT: • Diabetes Prevention Program Outcomes Study (DPPOS) lifestyle arm • HEALTHY Study: school-based nutrition and physical activity changes to reduce risk factors for type 2 diabetes • Treatment Options for type 2 Diabetes in Adolescents and Youth (TODAY) Study lifestyle arm • Diabetes Prevention and Control projects (R18) include providing DPP LS intervention in YMCA setting, culturally sensitive approaches to lifestyle change, etc. • Dietary treatment for inborn errors of metabolism—Clinical studies to test new dietary treatments (PAR-06-387) • Nuclear receptor research—Nuclear Receptor Signaling Atlas (e.g., role of dietary lipids as nuclear receptor ligands) • Special Statutory Funding Program for Type 1 Diabetes Research funds several nutrition-related programs, including: TEDDY (The Environmental Determinants of Diabetes in the Young study), TrialNet, and TRIGR (Type 1 Diabetes in the Genetically at Risk study)

  12. NIDDK’s Division of Kidney, Urologic, and Hematologic Diseases: Nutrition-Related Programs INVESTIGATOR INITIATED: • Iron Metabolism • Nutrition in Kidney Disease Patients • Kidney Stones • Mineral Nutrition • Obesity and Urologic Disease INITIATIVE SUPPORT: • Chronic Renal Insufficiency Cohort (CRIC) • Prospective Cohort Study of Kidney in Children (CKiD) • Program to Reduce Incontinence by Diet and Exercise (PRIDE) Clinical Trial

  13. Examples of NIH Initiatives Related to Obesity/Nutrition Ongoing initiatives: • PAR-07-259 and 06-103 Improving Diet and Physical Activity Assessment (R01 and R21) • PA-07-218 Diet Composition and Energy Balance (R01) • PA-08-078 Research on the Economics of Diet, Activity, and Energy Balance (R01) • PA-07-013 Research on Improving Health Care for Obese Patients (R01) • PA-07-180 School-based Interventions to Prevent Obesity (R01) • PAR-06-532 Translational Research for the Prevention and Control of Diabetes and Obesity (R18) Additional opportunities listed in the NIH Guide:http://grants2.nih.gov/grants/guide/

  14. NIDDK Major Areas of Focus • Maintain vigorous investigator-initiated research portfolio • Support pivotal clinical studies and trials • Preserve stable pool of talented new investigators • Foster exceptional research training and mentoring opportunities • Ensure knowledge dissemination through outreach and communications

  15. Focus Area:Vigorous Investigator-Initiated Research Portfolio • Promote innovation and problem-solving by individual investigators crucial for research progress. • Maintain commitment to a vigorous investigator-initiated research portfolio at the highest possible level. • Maximize investments through cross-cutting research applicable to disease-specific research issues. • 66% of current NIDDK budget devoted to RPGs, with 66% of RPG budget for investigator-initiated R01s

  16. Focus Area:Pivotal Clinical Studies and Trials • Support clinical studies and trials on a range of nutrition-related diseases, including:-HEALTHY Study of school-based nutrition and physical activity changes to reduce risk factors for type 2 diabetes-Nonalcoholic Steatohepatitis Network Trials of Vitamin E or insulin-sensitizing drugs in adults and children-Program to Reduce Incontinence by Diet and Exercise (PRIDE) • Strive for substantial minority participation • Maximize investment in clinical research by expanding access to research resources through ancillary studies and repositories

  17. Focus Area:New Investigators • Sustaining support for new investigators is both an NIH and a Congressional priority • Bring innovative ideas and fresh perspectives that invigorate research. • Strive to ensure new investigators realize their potential. • Foster mentorship activities and promote special consideration for funding new investigators. • 118 new investigators funded last year by DK; 116 to date this year • 15% of DK competing RPG budget for new investigator R01s; 21% of DK competing R01 budget for new investigator R01s

  18. Focus Area:Research Training and Mentoring • Maintain pipeline of outstanding investigators focused on NIDDK-related issues as critically important to research progress. • Continue to support undergraduate/ graduate/postdoctoral training opportunities, as well as research career development awards. • K awardee training; plan for helping 1st-time R01 recipients increase chance of renewal • Analyze data to optimize deployment of research training resources.

  19. Focus Area: Outreach and Communications • NIDDK Website • Educational/ awareness campaigns • Workshops, Conferences • Yearly compendium of Institute-sponsored research advances and opportunities

  20. Focus Area: Outreach and Communications http://www.niddk.nih.gov

  21. National Nutrition-Related Health Information Resources • Weight-control Information Network http://win.niddk.nih.gov/ • National Digestive Diseases Information Clearinghousehttp://digestive.niddk.nih.gov • National Kidney and Urologic Diseases Information Clearinghousehttp://kidney.niddk.nih.gov • National Diabetes Information Clearinghousehttp://diabetes.niddk.nih.gov/ • National Endocrine and Metabolic Diseases Information Servicehttp://www.endocrine.niddk.nih.gov

  22. Focus Area:Outreach and Communications http://www.celiac.nih.gov

  23. Focus Area:Outreach and Communications Workshops, Meetings on Topics Relevant to Nutrition Research Recent Meetings: • Gastrointestinal Microbiota and Advances in Prebiotic and Probiotic Research, December 11-12, 2007, Rockville, MD • 2007 Intrauterine Environment Investigators’ Meeting and Workshop Upcoming Meetings: • Workshop on the Establishment, Maintenance, & Turnover of Fat Depots, May 21-22, 2008, Lister Hill Auditorium, NIH, Bethesda, MD • Diabetes and Obesity Disparities in Healthcare Systems Conference, June 30-July 1, 2008, Natcher Auditorium, NIH, Bethesda • Neuroimaging in Obesity Research, October 27-28, 2008, Natcher Auditorium, NIH, Bethesda • Dynamic Epigenome and Metabolic Syndrome, November 2008, Washington DC.

  24. Focus Area:Outreach and Communications http://www.niddk.nih.gov • Features: • We Can! (Ways to Enhance Children’s Activity and Nutrition) • New Metabolic Clinical Research • Unit • Research Advances: • Omega-3 fatty acids reduce T1D risk in kids • Newly discovered molecular regulators of metabolism • Gut bacterial effects on metabolic efficiency and obesity risk • Dietary oxalate and kidney stones

  25. For More Information http://www.niddk.nih.gov http://dnrc.nih.gov

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