IBA Particle Therapy BU Damien Prieels, Research Manager

1. Loïc Grevillot PhD Student ENLIGHT-PARTNER Valencia IFIC 19/06/09 A reference Monte Carlo platform to assess radiation quality in hadron therapy (protons & carbon ions). • IBA Particle Therapy BU • Damien Prieels, Research Manager • Damien Bertrand, Research Project Manager • Creatis-LRMN RIO Team • David Sarrut, CNRS Researcher (PhD Director)‏ • Nicolas Freud, Assistant Professor

2. Presentation Plan • Introduction • Geographical context • Goal of the project • Overview of the project • Imaging & computing • Irradiation system • Validation • Conclusion • Limitations of the project • Status from January 2009 • Early results 2

3. IBA Léon Bérard Cancer Centre Creatis-LRMN lab Geographical context • ESR @ IBA, LLN, Belgium • ETOILE, Lyon, France as a secondary partner 3

4. Goal of the project • To be able to compare treatment plans from a commercial Treatment Planning System (TPS), with Monte Carlo (MC) simulations, for proton and carbon ion beams, focusing on active beam delivery. 4

5. Overview of the project • Ray tracing • Pencil beam • Others ? • Be able to compare treatment plans from a commercial TPS with my MC simulations, for protons and carbon ions beam, for active beam delivery only. • The research tool developed should be able to compute output relevant to radiobiology. VALIDATION • Beam • Energies • Intensities • Directions • Bragg peaks • SOBP • Spot size • Energy spread • etc. ? 5

6. Overview of the project • Proton: “easy”: • A lot of centres and experience • Data are accessible for validation • Commercial TPS exist • Carbon ions “real research begins”: • Less centres and experience • Less fundamental data accessible • Need to merge biology within physics simulations • No commercial TPS accessible 6

7. Overview of the project Imaging & Computing part • dd Validation part The irradiation system 7

8. Limitations of the project • Radiobiological models implementation • German model (LEM)‏ • Japanese model • Czech Republic model • Other models? • Fundamental data limits • Carbon fragmentation • RBE uncertainty • Uncertainty on the ionizing • potential of water • & human tissues • Collaborations are welcome! 8

9. Status from January 2009 • Working on protons only: • Looking at the physics list • Looking at the relevant parameters • => First interesting results are waiting for validation against • measurements, that should be done this summer. • Objectives: • To validate proton simulations. • To simulate a proton plan with the Gate MC platform. • To extend to carbon beams & address radiobiological issues. 9

10. Early results 10

11. Early results 11

12. Early results 12

13. Thank you! This work is performed within the PARTNER research programme, with financial support from the European Commission (FP7-People/ITN Grant nr. 215 840). 13

14. The computing part Imaging & Computing part • dd • Beam: • HU to convert into : • Energies • Intensities • Directions • Medium • Stopping Power Research part Computing & research part 14

15. The irradiation system • dd Computing part The irradiation sytem • Bragg peaks • SOBP • Spot size • etc. ? Research part 15

16. The validation part • Gate/Geant4 • Physics list • Electromagnetic & Hadronic • Relevant parameters of a simulation • Cut, Step size, ..., others? • Accuracy/Efficiency compromise • Radiobiological models implementation • Beam quality assessment: • LET by particle nature • Energy spectrum by particle nature • Particle spectrum in the medium • Biological dose calculation • dd Computing part Validation part Computing & research part 16

17. Status: early results , the cut parameter230 MeV proton beam. cut 1 mm 6 mm cut 0,1 mm cut 1 µm 17

18. High cut e- e- e- e- e- • Low cut e- e- e- e- e- e- e- e- e- Status : early results step • High cut => high step => lower accuracy • Low cut => lower step => better accuracy, but time issues 18

19. 5,8 mm Status: early results , the cut parameter230 MeV proton beam. Time issues 19