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Blueprint of Life Topic 10: Sutton and Boveri

Blueprint of Life Topic 10: Sutton and Boveri. Biology in Focus, HSC Course Glenda Childrawi , Margaret Robson and Stephanie Hollis. DOT POINT(s). outline the roles of Sutton and Boveri in identifying the importance of chromosomes. Introduction.

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Blueprint of Life Topic 10: Sutton and Boveri

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  1. Blueprint of LifeTopic 10: Sutton and Boveri Biology in Focus, HSC Course Glenda Childrawi, Margaret Robson and Stephanie Hollis

  2. DOT POINT(s) • outline the roles of Sutton and Boveri in identifying the importance of chromosomes

  3. Introduction Towards the end of the 19th century, cytology (the study of cells) was the scientific area of research that was in vogue, with many important discoveries being made at around the turn of the century. This is not surprising, since compound light microscopes had advanced to a point where they no longer produced distorted images, becoming the ‘new technology’ used to reveal the wonders of what lies within ells and to validate evidence for new theories. parkerlab.bio.uci.edu

  4. Introduction At that time, the challenge facing biologists was to determine what material in the cell held the hereditary factors. A common belief in those days was that protein would turn out to be hereditary material, because protein was present in both the cytoplasm and the nucleus. faculty.fmcc.suny.edu

  5. Introduction There was also a flurry of activity to validate or disprove Mendel’s findings in the late 1800s and to test whether they could be applied to organisms other than pea plants. creationrevolution.com

  6. Boveri and Sea Urchins Theodor Boveri, a German biologist, was one of the leading cytologists at the turn of the century. Between 1896 and 1904, he carried out experiments on sea urchin eggs, studying the behaviour of the cell nucleus and chromosomes during meiosis and after fertilisation. idw-online.de

  7. Boveri and Sea Urchins Sea urchin eggs were ideally suited for study because they could be easily fertilised in a laboratory and have a quick (48 hour) time frame for larval development. Boveri’sstudies were advanced for his time, as he did not simply rely on observations made with a microscope, but also solved problems by experimenting with the larvae of sea urchins. www.thorntonsrestaurant.com

  8. Boveri and Sea Urchins It was already known at the time that each species of living organism has a set number of chromosomes and that, during fertilisation, an egg cell and a sperm cell fuse. Boveri’sexperimental work with sea urchins showed that the nucleus of the egg and sperm each contribute the same amount (50%) of chromosomes to the zygote (fertilised egg), making a connection between chromosomes and heredity. www.ubqool.com

  9. Boveri and Sea Urchins His experiments showed: ■ when a normal egg and sperm fused, the resulting offspring showed characteristics of both parents counsellorsofwisdom.com

  10. Boveri and Sea Urchins His experiments also showed: ■ that if the nucleus of only one parent was present, the larvae resembled that parent, but showed abnormalities. When an egg, whose nucleus had been removed, was fertilised with a sperm, the resulting sea urchin larvae showed characteristics similar to the male parent. However, they were smaller, had only half the normal number of chromosomes and showed some abnormalities. ocean.nationalgeographic.com

  11. Boveri and Sea Urchins From his experiments he deduced that: • a complete set of chromosomes (that is, chromosomes in pairs)is needed for normal development • the inheritance ‘factors’ are found on chromosomes within the nucleus (chromosomes are the carriers of heredity) web1.beverlyhg-h.schools.nsw.edu.au

  12. Boveri and Sea Urchins From his ongoing studies, he realised that there are more hereditary ‘factors’ than chromosomes and so deduced that there must be many factors (today known as genes) on one chromosome. www.bbc.co.uk

  13. Sutton and Grasshoppers Walter Sutton (1877–1916), an American cytologist, studied meiosis in cells of grasshoppers (Brachystola magna). In contrast to the eminent Boveri, Sutton was a young, unknown graduate student who produced remarkable and detailed drawings of his findings in cytology. www.kumc.edu

  14. Sutton and Grasshoppers As a result of his observations, he made the connection between the behaviour of chromosomes during meiosis and Mendel’s laws of heredity. His independent findings (1902–4), together with those of Boveri (1902), formed the basis of the chromosome theory of inheritance. www.biology.iupui.edu

  15. Sutton and Grasshoppers Sutton’s observations of meiosis in grasshoppers revealed that: ■ chromosomes occur in distinct pairs, visible during meiosis in grasshopper cells; one chromosome of each pair is paternal and the other maternal (today termed homologous pairs) and the chromosomes in each pair have the same size and shape pk-photography.blogspot.com

  16. Sutton and Grasshoppers Sutton’s observations of meiosis in grasshoppers revealed that: ■ during meiosis (reduction division), the chromosome number of a cell is halved: the chromosomes in each pair of chromosomes separate (just like Mendel’s factors segregate—his law of dominance and segregation) and each gamete receives one chromosome from each pair ■ fertilisation restores the full number of chromosomes in the zygote. www.tutorvista.com

  17. Sutton and Grasshoppers He concluded that chromosomes were the carriers of heredity units and behaved in the same manner as Mendel’s ‘factors of inheritance’ (genes). www.beltina.org

  18. Sutton and Grasshoppers In addition, Sutton stated that: ■ Chromosomes arrange themselves independently along the middle of the cell just before it divides—that is, they assort independently of each other during segregation, like Mendel’s factors (evidence for Mendel’s law of independent assortment) www.downsyndrome.org.za

  19. Sutton and Grasshoppers In addition, Sutton stated that: ■ Chromosomes are units involved in inheritance. Sutton, like Boveri, also believed that several Mendelian‘factors’ must be present in one chromosome and could therefore be inherited as a unit. (This is what we term ‘linkage’ today. It will be dealt with in more detail later). www.scienceclarified.com

  20. Response of the scientificcommunity at the time Boveri and Sutton’s chromosome theory linking chromosomes and heredity was regarded with scepticism by many, but accepted by others, causing much discussion and debate in the early part of the 20th century. As is common in science, Sutton and Boveri’sdeductions became hypotheses for testing in future experiments— scientists set about trying to validate or disprove these findings. a

  21. Response of the scientificcommunity at the time With advances in scientific understanding and improved technology, their cytological interpretation of Mendelian inheritance was convincingly confirmed in 1915 and still holds today. www.transtutors.com

  22. Activity -Handout 10.1.3 Sutton and Boveri Chart -Students to complete Sutton and Boverifindings worksheet a

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