Probe-Level Data Normalisation: RMA and GC-RMA. Sam Robson Images courtesy of Neil Ward, European Application Engineer, Agilent Technologies. References. “ Summaries of Affymetrix Genechip Probe Level Data” , Irizarry et al., Nucleic Acids Research, 2003, Vol. 31, No. 4.
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Images courtesy of Neil Ward, European Application Engineer, Agilent Technologies.
μin=Log scale expression level (RMA measure).
αjn = Probe affinity affect.
εijn = Independent identically distributed error term (with mean 0).