Effects of Type II diabetes on coronary vasodilation. By Matthew Cozier Research Project 3003MSC Supervisor: Roselyn Rose'Meyer Lab partners; Lynette Burges & Katie Crane. Overview. Aims & Hypothesis Introduction Epidemiology of diabetes, Effects of hyperglycemia
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Type II diabetes affects the mechanism of ischemia induced vasodilation, and potentiates the risk of coronary heart disease.
(Cozier et al., 2008)
† Hanley AJ, Williams K, Stern MP, Haffner SM (2002): Homeostasis model assessment of insulin resistance in relation to the incidence of cardiovascular disease: the San Antonio Heart Study. Diabetes Care 25: 1177–1184, 2002.
* Diabetes Atlas. Gan D, Ed. Brussels, Belgium, International Diabetes Federation, 2003
High prevalence of type II diabetes high –associated with increased obesity
Suboptimal provision of health care for diabeticsWorldwide mortality of diabetes
(Wild et al., 2000)
Wild SH., Roglic G., Green a., Sicree R., King H., Global Prevalence of Diabetes. Estimates for the year 2000 and projections for 2030. Diabetes Care 27;(5)1047-1053
* de Courten M, Zimmet P (1997) Screening for non-insulin-dependent diabetes mellitus: where to draw the line. Diabet Med 14: 95±98
Danaei G., Lawes C.M., Vander Hoorn S., et al., Global and regional mortality from ischaemic heart disease and stroke attribute to higher-than-optimum blood glucose concentration: Comparative risk assessment. Lancet. 2006; 368:1651-1659.
Mechanism of Action. NO → NO receptor → cGMP → PKG → Relaxation of Smooth muscle.
Nitroprusside - NO receptor Agonists;
Adenosine → A2 Adenosine Receptors → cAMP → PKA → K-ATP channel activation → Hyperpolarisation of the cell membrane → vasodilation.
A link between metabolic state of the heart and function of the cardiac vasculature.
NECA; Adenosine Analogue
Diazoxide; K-ATP channel opener
Normal Function of the heart
Tissue Necrosis & Tissue Damage
Green = Vasodilation
Red = No Vasodilation
Langendorf reperfusion apparatus...
* P < 0.05 vs Control
* P < 0.05 vs Control
All aims have been achieved; experiment successful.
Lynette Burges & Katie Crane