Anthrax, Smallpox and Multiple Vaccinations: What We Know and Do Not Know. Omowunmi (‘Wunmi) Osinubi, MD, M.Sc., MBA, FRCA. Adjunct Assistant Professor Department of Occupational and Environmental Health UMDNJ-School of Public Health & Robert Wood Johnson Medical School
Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.
Omowunmi (‘Wunmi) Osinubi, MD, M.Sc., MBA, FRCA.
Adjunct Assistant Professor
Department of Occupational and Environmental Health
UMDNJ-School of Public Health & Robert Wood Johnson Medical School
Occupational Health Physician
War Related Illness and Injury Study Center
Encephalitis Virus Era)
Ebola/MarbugBiological Warfare Agents of Concern
The Anthrax Letters
Patient at rest, bilateral mild ptosis, disconjugate gaze, symmetric facial muscles.
Requested to perform max. smile. Ptosis, disconjugate gaze, mild asymmetric smile.
? Efficacy against inhalational anthrax
? Manufacturing quality control problems
? Short and long-term side effects
? Vaccine components and adjuvants
“Squalene” vs Aluminium hydroxide hypotheses
? Military policies that first mandated vaccinations, punished refusals for vaccinations and later retracted mandatory vaccination
? Indications for vaccinations was not uniformly applied
? Vaccinations performed in “secrecy”, inadequate informed consent, and incomplete documentation of anthrax vaccinations
? Variability in vaccines used
(cited by the 2002 IOM report on AVA)
So Why Should We Care Era)about Veterans’ Vaccination concerns?
Because they cared for us
Authier FJ, Sauvat S, Champey J, Drogou I, Coquet M, Gherardi RK. Chronic fatigue syndrome in patients with
macrophagic myofasciitis. Arthritis Rheum. 2003;48:569-570.
Centers for Disease Control and Prevention. SMALLPOX FACT SHEET. Side Effects of Smallpox Vaccination.
Cherin P, Gherardi RK. Macrophagic myofasciitis. Curr Rheumatol Rep. 2000;2:196-200.
Dire DJ. CBRNE - Biological Warfare Agents. http://emedicine.medscape.com/article/829613-overview
Geier DA, Geier MR. Anthrax vaccination and joint related adverse reactions in light of biological warfare
scenarios. Clin Exp Rheumatol. 2002;20:217-220.
Geier MR, Geier DA. Gastrointestinal adverse reactions following anthrax vaccination: an analysis of the
Vaccine Adverse Events Reporting System (VAERS) database. Hepatogastroenterology. 2004;51:762-767.
Gherardi RK, Coquet M, Cherin P, et al. Macrophagic myofasciitis lesions assess long-term persistence of
vaccine-derived aluminium hydroxide in muscle. Brain. 2001;124:1821-1831.
Petrik MS, Wong MC, Tabata RC, Garry RF, Shaw CA. Aluminum adjuvant linked to Gulf War illness induces motor
neuron death in mice. Neuromolecular Med. 2007;9:83-100.
Research Advisory Committee on Gulf War Veterans’ Illnesses. Gulf War Illness and the Health of Gulf War Veterans:
Scientific Findings and Recommendations. Washington, D.C.: U.S. Government Printing Office, November 2008
Steele L. Prevalence and patterns of Gulf War illness in Kansas Veterans: association of symptoms with
characteristics of person, place, and time of military service. Am J Epidemiol. 2000;152:992-1002.
Takafuji ET, Russell PK. Military immunizations. Past, present, and future prospects. Infect Dis Clin North
U.S. Department of Defense, Office of the Special Assistant for Gulf War Illnesses. Information Paper:
Vaccine Use During the Gulf War. Washington, D.C. Dec 7, 2000.
United States Government Accountability Office. GAO-07-787R DOD’s health care Centers Network. Washington DC,
June 2007. http://www.gao.gov/new.items/d07787r.pdf
Wells TS, Sato PA, Smith TC, Wang LZ, Reed RJ, Ryan MA. Military hospitalizations among deployed US service
members following anthrax vaccination, 1998-2001. Hum Vaccin. 2006 Mar-Apr;2(2):54-9. Epub 2006 Mar 13.