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Membrane Transport

Membrane Transport. Chp. 3, 5. Fluid compartments Membrane structure Movement of electrolytes other solutes and water - Passive transport - Active transport Chemical equilibrium Electrical equilibrium The membrane potential. Outline. Body Fluid Compartments. Figure 3-2.

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Membrane Transport

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  1. Membrane Transport • Chp. 3, 5

  2. Fluid compartments Membrane structure Movement of electrolytes other solutes and water - Passive transport - Active transport Chemical equilibrium Electrical equilibrium The membrane potential Outline

  3. Body Fluid Compartments Figure 3-2

  4. Fluids are separated by the cell membrane

  5. Fluid compartments Membrane structure Movement of electrolytes other solutes and water - Passive transport - Active transport Chemical equilibrium Electrical equilibrium The membrane potential Outline

  6. Cell Membrane: Function • Physical barrier • Gateway for exchange • Communication • Cell structure • Phospholipid bilayer

  7. Cell Membrane: Structure The fluid mosaic model of a biological membrane Figure 3-4

  8. Lipids Micelles Liposomes Sphingolipids Proteins Integral Peripheral Lipid-anchored Cell Membrane: Composition

  9. Cell Membrane: Formation Membrane phospholipids form bilayers, micelles, or liposomes Figure 3-5a

  10. Cell Membrane: Formation Figure 3-5b

  11. Cell Membrane: Proteins The three types of membrane proteins: integral, peripheral, and lipid-anchored Figure 3-6

  12. Cell Membrane Map of cell membrane components Figure 3-9

  13. Fluid compartments Membrane structure Movement of electrolytes other solutes and water - Passive transport - Active transport Chemical equilibrium Electrical equilibrium The membrane potential Outline

  14. Distribution of Epithelia in the Body Figure 3-24

  15. Exchange Epithelia • Leaky junctions • Rapid transport • Oxygen • Carbon dioxide • Ions and fluids • Capillaries and lung alveoli

  16. Exchange Epithelia Figure 3-25a

  17. Transporting Epithelia • Exchange of ions and nutrients • Tight junctions • Intestine and kidney

  18. Transporting Epithelia Figure 3-25b

  19. Fluid compartments Membrane structure Movement of electrolytes other solutes and water - Passive transport - Active transport Chemical equilibrium Electrical equilibrium The membrane potential Outline

  20. Fluid compartments Membrane structure Movement of electrolytes other solutes and water - Passive transport - diffusion - facilitated diffusion - osmosis - Active transport Chemical equilibrium Electrical equilibrium The membrane potential Outline

  21. Figure 5-5

  22. Diffusion: Seven Properties • Passive process • High concentration to low concentration • Net movement until concentration is equal • Rapid over short distances • Directly related to temperature • Inversely related to molecular size • In open system or across a partition

  23. Simple Diffusion Fick’s law of diffusion Figure 5-6

  24. Permeable to: H2O Lipids Gases Small neutral molecules Impermeable to: Large molecules Charged molecules Cell membrane

  25. Large molecules and charged molecules cannot cross the phospholipid bilayer. They have to use special channels to cross (movement well controlled) or They have to pass through spaces between cells (movement not so tightly controlled) Cell membrane permeability

  26. Fluid compartments Membrane structure Movement of electrolytes other solutes and water - Passive transport - diffusion - facilitated diffusion - osmosis - Active transport Chemical equilibrium Electrical equilibrium The membrane potential Outline

  27. Figure 5-13b

  28. Figure 5-14

  29. Figure 5-15

  30. Fluid compartments Membrane structure Movement of electrolytes other solutes and water - Passive transport - diffusion - facilitated diffusion - osmosis - Active transport Chemical equilibrium Electrical equilibrium The membrane potential Outline

  31. Figure 5-29 - Overview

  32. Table 5-6

  33. Table 5-7

  34. Figure 5-30 - Overview

  35. Figure 5-31 - Overview

  36. Table 5-8

  37. Table 5-9

  38. Fluid compartments Membrane structure Movement of electrolytes other solutes and water - Passive transport - diffusion - facilitated diffusion - osmosis - Active transport Chemical equilibrium Electrical equilibrium The membrane potential Outline

  39. Molecules are carried from low concentration to high conc. areas Active transport Figure 5-16

  40. Table 5-2

  41. Table 5-3

  42. Figure 5-18 - Overview

  43. Figure 5-23 - Overview

  44. Figure 5-24 - Overview

  45. Figure 5-24, step 1

  46. Figure 5-27 - Overview

  47. Fluid compartments Membrane structure Movement of electrolytes other solutes and water - Passive transport - diffusion - facilitated diffusion - osmosis - Active transport Chemical equilibrium Electrical equilibrium The membrane potential Outline

  48. Chemical equilibrium • Compounds will move between the various fluid compartments depending their concentrations, permeability and the presence of carriers

  49. Figure 5-25

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