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Immunologiskt minne. Kursbok: ”The immune system” Peter Parham Kapitel 8.21-8.25

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Immunologiskt minne. Kursbok: ”The immune system” Peter Parham Kapitel 8.21-8.25. Immunological memory: ability of the immune system to respond more rapidly and effectively to pathogens that have been encountered previously.

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slide1

Immunologiskt minne.

Kursbok: ”The immune system” Peter Parham

Kapitel 8.21-8.25

slide4

Immunological memory: ability of the immune system to respond more

  • rapidly and effectively to pathogens that have been encountered previously.
  • Pre-existence of a clonally expanded population of antigen-specific
  • lymphocytes. Secondary, tertiary, and so on … memory responses also
  • differ in the quality from the primary response. For example, the
  • characteristics of antibodies produced in secondary and subsequent
  • responses are distinct from those produced in the primary response to the
  • same antigen.
  • It is still not clear today if memory reflects a long-lived population of
  • specialized memory cells or depends on the persistence of undetectable
  • levels of antigen that continuously re-stimulate antigen-specific
  • lymphocytes.
slide5

2 possibilities:

  • memory is sustained by long-lived lymphocytes, induced by the original
  • exposure, that persist in a resting state until a new encounter with the
  • same pathogen.
  • b) Lymphocytes originally activated by the pathogen are repeatedly
  • re-stimulated, even in the absence of re-infection with the pathogen.
  • Pathogen subsists in a small amount so as to not have the capacity to
  • induce a new infection, but still can re-stimulate the activated lymphocytes.
  • This re-stimulation could occur via the follicular dendritic cells.
  • Specific cytokines could mediate re-stimulation.
slide9

CD45RO som finns på minnesceller binder

mycket bättre till TCR/CD3 komplex och gör

så att den överförda signalen kommer fram

mycket mera effektivt på ett minnescell än

på en naiv cell.

slide10

Antibody can suppress naiv B cell activation by crosslinking

the B-cell antigen receptor

Det är ju direkt onödigt att sätta igång med en helt ny process när man

kan få effektiva och snabba svar med minnesceller.

Preexisting

soluble

antibody

ITIM

slide13

Immune complexes bound to follicular dendritic cells (FDC) form

ICCOSOMES. Antigen can persist in this form for long periods.