Autoimmunity III. Therapeutics of Autoimmune Diseases. General Ag-specific Gene therapy IVIg Plasmapheresis BMT. Specific SLE RA MS. Autoimmune Therapeutics. Antigen-specific Therapy. Induce tolerance Determined by Form and purity of Ag Dose Route of administration
Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.
Therapeutics of Autoimmune Diseases
of MHC class II antigens
by statins on
T lymphocytes activation.
and IL-2 release (b)
measured in allogenic
T lymphocytes exposed
to human ECs pre-treated
for 48 h with
IFN- (500 U/ml) alone (1),
or IFN- (500 U/ml) with
atorvastatin (10 M) (2).
Numerous other practical clinical applications for using statins as immunomodulators, particularly in diseases where aberrant expression of MHC class II molecules are implicated.
This ranges from autoimmune diseases such as:
type I diabetes, multiple sclerosis and rheumatoid arthritis to psoriasis and chronic inflammatory diseases like atherosclerosis.
The high degree of patient tolerance of statins makes them potentially a welcome addition to the limited current arsenal of immunosuppressive agents.