Autoimmunity I. Matt McReynolds. Definition Direct proof Indirect evidence Circumstantial Diseases Antibody-mediated Immunecomplex-mediated T cell-mediated Models. Outline. Autoimmunity. “Friendly-fire”: Immune response to self Autoimmune disease:
When the immunological recognition of self with the involvement of antibody, complement, immune complexes, and cell-mediated immunity progresses from being benign to pathologic.
An axial FLAIR (fluid-attenuated inversion recovery) image shows multiple ovoid and confluent hyperintense lesions in the periventricular white matter (Panel A). Nine months later, the number and size of the lesions have substantially increased (Panel B).
Noseworthy, et al. NEJM 2000.
After the administration of gadolinium, many of the lesions demonstrate enhancement, indicating the breakdown of the BBB (Panel C). In Panel D, a parasagittal T1-weighted MRI scan shows "black holes" in the periventricular white matter and corpus callosum (chronic lesions).