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  1. A p-PKB p-GSK3 ** - - - - ** * + + + + ** L 1.5 1.5 - - - - + + + + ** ** LY Fold Increase 1.0 1.0 p-PKB Fold Increase 0.5 0.5 p-GSK3 0.0 0.0 C LY L L+LY C LY L L+LY Total PKB Treatment Treatment I p-GSK3 p-PKB * LY * ** ** 2 p-PKB 2 ** Fold Increase ** Fold Increase p-GSK3 1 1 Total PKB 0 0 Treatment Treatment - - + + L B - - + + LY p-MAPK * C C C LY LY LY I I I I+LY I+LY I+LY p-MAPK ** p-MAPK ** 2 ** 1.5 * * Total PKB Fold Increase Fold Increase 1 1.0 I 0.5 - - 0 LY + + - - p-MAPK 0.0 + + C LY L L+LY Treatment Total PKB Treatment