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Exploring Muscle Structure and Physiology: Insights into Contraction Mechanism and Clinical Implications

Delve into skeletal muscle fibers, excitation-contraction coupling, and pathology examples in this study of muscle physiology. Discover the sliding filament model, myosin filament formation, and more.

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Exploring Muscle Structure and Physiology: Insights into Contraction Mechanism and Clinical Implications

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  1. MUSCLE STRUCTURE AND PHYSIOLOGY J. Rosenbluth, April 2012

  2. MUSCLE • Skeletal muscle fibers • Contraction mechanism • Excitation-contraction coupling • Gross properties of skeletal muscle • Pathology/Clinical examples

  3. Myofibrils

  4. Skeletal muscle band pattern

  5. Double “antiparallel” array of myofilamnts (H.E.Huxley)

  6. Sliding filament model

  7. Myosin filament formation

  8. Low-angle X-ray diffraction of skeletal muscle (meridional pattern)

  9. Decorated F-actin

  10. Antiparallel array of myofilaments

  11. Double hexagonal array (vertebrate skeletal muscle)

  12. Crossbridge position during relaxation (top) vs contraction (bottom)

  13. Attached Released Cocked Force generating Attached Cross-bridge Cycle

  14. Triads (amphibian)

  15. Skeletal muscle triad (amphibian)

  16. Triad structure

  17. Actin filament with Tr and Tm

  18. Tropomyosin movement

  19. Pennate Muscles

  20. Length-Tension Relationship

  21. Load-Velocity Relationship

  22. Twitch vs Tetanic Tension

  23. Fiber types (cat gastrocnemius)

  24. Twitch contraction times

  25. Skeletal Muscle Fatigue

  26. “Winging”(facio-scapulo-humeral dystrophy)

  27. “Pseudohypertrophy” (Duchenne dystrophy)

  28. Charcot-Marie-Tooth disease

  29. Spinal muscular atrophy

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