CARDIAC REGULATION - PowerPoint PPT Presentation

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CARDIAC REGULATION

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  1. CARDIAC REGULATION EXTRINSIC AND INTRINSIC MECHANISMS Guido E. Santacana Ph.D. Professor Dept. of Physiology

  2. Control of Cardiac Activity CARDIAC OUTPUT = HEART RATE X STROKE VOLUME Pacemaker Activity Myocardial Performance TWO POINTS TO REGULATE

  3. EXTRINSIC REGULATION • AUTONOMIC NERVES • BARORECEPTOR REFLEX • BAINBRIDGE REFLEX • RESPIRATORY EFFECTS • CHEMORECEPTOR REFLEXES • VENTRICULAR RECEPTOR REFLEX • HORMONAL REGULATION

  4. EXTRINSIC REGULATION HEART AND BLOOD VESSELS

  5. EXTRINSIC INNERVATION OF THE HEART THORACIC CERVICAL MEDULLA OBLONGATA R VAGUS EPICARDIAL PLEXUS SAN L CORONARY VESSELS AVN MYOCARDIUM

  6. SYMPATHETIC VS VAGAL STIMULATION AND DECAY VAGAL HEART RATE (B/MIN) SYMPATHETIC

  7. PARASYMPATHETIC / SYMPATHETICREASONS FOR STIMULATION/DECAYDIFFERENCES VAGUS SYMP. DIFUSSION Ach NPY NE K+ REUPTAKE ATROPINE NE Ach B BLOCKERS B1 M AchE cAMP

  8. EFFECTS OF CATECHOLAMINES EPINEPHRINE NOREPINEPHRINE

  9. BARORECEPTOR REFLEX AORTIC ARCH CAROTID SINUS 200 HEART RATE B/M 50 150 ARTERIAL PRESSURE mmHg

  10. BAINBRIDGE VS BARORECEPTOR REFLEXES VOLUME LOAD + + ARTERIAL PRESSURE CO INCREASED RA PRESSURE + + ATRIAL RECEPTORS BARORECEPTOR REFLEX + - BAINBRIDGE REFLEX + HEART RATE

  11. RESPIRATORY REGULATION OF CARDIAC ACTIVITY INSPIRATION BARORECEPTOR REFLEX + + ARTERIAL PRESSURE INTRATHORACIC PRESSURE CO + + VENOUS RETURN BAINBRIDGE

  12. PERIPHERAL CHEMORECEPTORS AND HEART RATE + - PERIPHERAL CHEMORECEPTORS HEART RATE MEDULLA + - DAMPENING OF CARDIAC EFFECT RESPIRATORY ACTIVITY

  13. VENTRICULAR RECEPTOR REFLEX VASOVAGAL SYNCOPE STANDING VENTRICULAR CONTRACTION VENOUS POOLING SYMPATHETIC ACTIVITY CO MAP BARO REFLEX VENOUS RETURN

  14. HUMORAL REGULATION INSULIN THYROID GLUCAGON dP/dt CATECHOLAMINES POTENTIATION STEROIDS

  15. RENIN-ANGIOTENSIN

  16. ATRIAL NATRIURETIC PEPTIDE

  17. ENDOTHELIN

  18. ANTIDIURETIC HORMONE

  19. INTRINSIC REGULATION • FRANK STARLING • HEART RATE AND FORCE

  20. INTRINSIC REGULATIONOF THE HEART FRANK STARLING LAW OF THE HEART AND BACK TO THE VENTRICULAR FUNCTION CURVE :>) LVP EDV

  21. FORCE DEVELOPMENT .32 FORCE DEVELOPED(G) 1.6 180 INTERVAL BETWEEN CONTRACTIONS(SEC)

  22. REGULATION OVERVIEW