Translational Case Histories. Harvard Medical School Center for Biomedical Informatics i2b2 National Center for Biomedical Computing Isaac S. Kohane, MD, PhD John Glaser, PhD Susanne Churchill, PhD. First signal: 1 year after Celecoxib 8 months after Rofecoxib.
Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.
Harvard Medical School
Center for Biomedical Informatics
i2b2 National Center for Biomedical Computing
Isaac S. Kohane, MD, PhD
John Glaser, PhD
Susanne Churchill, PhD
QIDS: Quick Inventory of Depressive Symptoms, self report
N = 943/2876
Very severe symptoms
Last QIDS-SR Score
Trivedi MH, et al. Am J Psychiatry 2006;163:28-40.
adds >95% specificity
Association in population samples 0.1 to 0.9)
SNP frequency in cases compared to controls
Positive controls: MHC, PTPN22, STAT4, TRAF1-C5, TNFAIP3
…...a 0.1 to 0.9)cgt…ggaatac…...
Protein protein interaction network
67 Conditions Total
Nuclear receptors: 31 of 67.
Interleukins: 38 of 67.
Insulin signaling: 45 of 67.