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Systolic BP variability significantly predicts the development of microalbuminuria

Visit-to-visit blood pressure variability is an independent risk factor of microalbuminuria in diabetic patients. Systolic BP variability significantly predicts the development of microalbuminuria. (SD = standard deviation; CV = coefficient of variation)

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Systolic BP variability significantly predicts the development of microalbuminuria

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  1. Visit-to-visit blood pressure variability is an independent risk factor of microalbuminuriain diabetic patients

  2. Systolic BP variability significantly predicts the development of microalbuminuria (SD = standard deviation; CV = coefficient of variation) * Adjusted for age, sex, duration of diabetes, number of visits, mean pressure, baseline HbA1c, and baseline eGFR) Noshad S, Mousavizadeh M, MozafariM, Nakhjavani M and Esteghamati A. J Hum Hypertens2014;28:37-43.

  3. Systolic BP variability significantly correlated with albuminuria variability (SBP = systolic blood pressure; SDIM = standard deviation independent of mean. a Standardized β-coefficient. b Multivariate models are adjusted for age, sex, duration of diabetes, number of visits, mean systolic pressure, baseline HbA1c and baseline eGFR.) Noshad S, Mousavizadeh M, MozafariM, Nakhjavani M, and Esteghamati A. J Hum Hypertens2014;28:37-43.

  4. Guideline recommendations about antihypertensive strategies to suppress systolic BP variability “…whatever the underlying mechanisms, systolic blood pressure variability appears to be an important independent predictor of clinical outcomes.” “…the updated guidance recommends the best available evidence-based treatment options to suppress blood pressure variability in people with hypertension.” ACE inhibitor/CCB is the preferred two-drug combination NICE 2006 NICE 2011 A A C C or D Step 1 NEW A+C or A+D A+C Step 2 A+C+D Ensure optimal dosages before step 3 Step 3 A+C +D* NICE Guidelines in Hypertension 2011

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