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Analysis of Dizziness, Somnolence, and Plasma Concentration in Brivaracetam Treatments

This study investigates the effects of Brivaracetam in various dosages (10 mg, 20 mg, 40 mg, 80 mg) on patients experiencing dizziness and somnolence. It features data on plasma concentrations (µg/mL) collected at different sampling points post-dose, alongside photosensitivity window measurements (Hz). The results highlight the relationship between Brivaracetam dosage, plasma concentration levels, and side effects, providing insight into safety and efficacy for managing treatment.

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Analysis of Dizziness, Somnolence, and Plasma Concentration in Brivaracetam Treatments

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  1. Kasteleijn-Nolst Trenité E-Figure 1 (B) (A) Dizziness 60 60 Somnolence Dizziness 100 100 50 50 40 40 10 10 GBP Plasma concentration (µg/mL) 30 Photosensitivity window (Hz) Photosensitivity window (Hz) Plasma concentration (µg/mL) 30 1 1 20 20 10 10 0.1 0.1 BRV BRV 0 0.05 0 0.05 PD 0.5 1 2 4 6 8 PD 0.5 1 2 4 6 8 24 28 PD 0.5 1 2 4 6 8 PD 0.5 1 2 4 6 8 24 28 Placebo Brivaracetam 20 mg Placebo Brivaracetam 10 mg Sampling points (hour post-dose) Sampling points (hour post-dose) (D) (C) 60 60 Dizziness 100 100 50 50 40 40 10 10 LTG Plasma concentration (µg/mL) Plasma concentration (µg/mL) Photosensitivity window (Hz) Photosensitivity window (Hz) 30 30 1 1 20 20 10 10 0.1 0.1 BRV BRV 0 0.05 0 0.05 PD 0.5 1 2 4 6 8 PD 0.5 1 2 4 6 8 24 28 32 48 72 PD 0.5 1 2 4 6 8 PD 0.5 1 2 4 6 8 24 28 32 48 72 Placebo Brivaracetam 80 mg Placebo Brivaracetam 40 mg Sampling points (hour post-dose) Sampling points (hour post-dose)

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