August 2013

1. Firm Leadership August 2013 WASHINGTON DC AUSTIN SAN FRANCISCO

2. History ADVI, a merger of HillCo HEALTH and AccelusHealth Partners was founded by Marc Samuels and Lawrence Leisure in 2013. Our team members translate the value of client products and services into the language and currency of payers, both public and private. In doing so we create value for new or existing clients by accelerating time to revenue and profitability with a higher degree of market certainty.

3. ADVI IS UNIQUE: Government, scientific, industry, payer, and professional consultancy experience and expertise in one company

4. ADVI Team Members • Consulting • Life Sciences • Digital Health • Managed Care • Services • Research • Market Research • Due Diligence • Idea Generation (B2B, B2G) • Analytics

5. Marc Samuels, JD, MPH Worked at the highest levels of national and Texas state politics • White House Office of Policy Development • Vice President’s Office • Pentagon Office of Health Affairs • Texas Health & Human Services Commission • Office of the Governor, State of Texas Involved in many of the most seminal policy issues across public and private payers • Coding and payment of molecular diagnostics • Drug Payment Reform • Quality and registry issues • Key overage decisions: EMEND, ESAs, EXACT SCIENCES, TAVR, VISUDYNE, ZEVALIN, PROVENGE Spoken and Published: In Vivo, Journal of Oncology Practice, Medical Economics, Health Systems Review; Managed Care Answer Book , HMO and Capitation Answer Book, published by Panel Publishers, New York • President and Chief Executive Officer Marc Samuels is the President and CEO of ADVI (formerly HillCo HEALTH). Samuels is responsible for the strategic vision, leadership and operational execution of the Company, as well as development and execution strategies designed to grow business outside of North America. He provides senior relationship management for the firm’s top clients across life sciences, digital health, managed care and services. He is a graduate of The University of Texas School of Law, Yale School of Medicine and the University of Michigan.

6. Lawrence Leisure Larry Leisure is the Chairman at ADVI. He also serves as a venture partner at Kleiner Perkins Caufield & Byers. He received his AB in economics from Stanford University and his MBA in finance from the University of California, Los Angeles. Distinguished career in healthcare serving in a number of senior consulting and management roles • Global Managing Partner, Accenture • Global Managing Partner, Towers Watson • Senior Vice President, Kaiser Permanente Client partner to many of the largest US health plans and PBMs • Aetna, CIGNA, UnitedHealth, and WellPoint • Caremark, ESI/MEDCO, MedImpact Well known industry leader and innovator • Co-founded Healthspottr, a new media focused on the acceleration of innovation in health care • Sits on the boards of several Silicon Valley health information and bioscience companies including Crescendo Bioscience, Medpedia, Navigenics, and Tethys Bioscience • Chairman

7. Michael Beebe Long and deep physician specialty relationships • Mr. Beebe spent 14 years at the AMA prior to joining ADVI; his most recent position was Director of CPT • He was a central participant in AMA advocacy efforts involving public and private coverage, coding and reimbursement issues; including provider class action litigation, CMS physician payment negotiations, and local coverage determinations • Senior Social Scientist in Physician Payment Systems where he was primary staff to the AMA/Specialty Society RVS Update Committee (RUC) Responsible for or involved in many of the most seminal product and service coding decisions • Molecular and companion diagnostics – created MAAA and NGS coding nomenclatures • Spinal techniques • Vaccines • Tele-monitoring • Wound Care and Skin substitutes • Cardiac Procedures, including TAVR and minimally invasive • Senior Vice President Michael Beebe, Senior Vice President, joined ADVI in 2008. Mr. Beebe advises clients on all aspects of reimbursement and strategic policy planning, including specific coding strategies in the physician office and the hospital or other health care provider settings. He directs ADVI’s device and diagnostic practices. Mr. Beebe has a Bachelor of Arts from Penn State University and a Master’s Degree from Boston University.

8. David Blaszczak Significant Investment/Equity Analyst Experience • Potomac Research Group • Washington Research Group • Schwab Capital Markets Notable Public Sector Experience at the Centers for Medicare and Medicaid Services (CMS) • MMA implementation • Health IT • Medicaid Solid State Government Experience • Maryland Office of the Attorney General • Maryland Department of Insurance • Senior Vice President & • General Manager, ADVI ADVISORS David Blaszczak, ADVI Senior Vice President, is widely recognized as one of the leading experts in medical technology, diagnostics, and pharmaceutical policy issues, with nearly a decade covering these issues for the investment community. He earned a Bachelor of Arts in Health Administration and Master’s in Public Policy from the University of Maryland, Baltimore.

9. Angela Lively Significant Industry Expertise • Amgen • Abbott Profound Consulting Experience • Avalere • DK Pierce • Covance Leader in Innovative Thinking • Evidence development, local and national payer strategy (Medicare, Medicaid, and commercial insurance), coding recommendations and support, advocacy development, and health policy change • Focused in the areas of nephrology, oncology, primary care, internal medicine, and cardiology • Projects include self-administered biologics, physician-administered drugs and biologics, dialysis supplies, and inpatient and outpatient products with unique drug delivery systems • Senior Vice President Angela Lively, Senior Vice President, leads the firm’s drugs and biologics practice. commercialization practice and has spent her career advising top biopharmaceutical companies on issues affecting patient access to new and innovative products. Ms. Lively completed her Masters in Social Work Social Policy with a concentration in health policy from The Catholic University of America and has a Bachelor of Arts degree in Psychology and Sociology from Baylor University.

10. Louis Jacques, M.D. A Distinguished Career in Government Service and in Medicine • Director, Coverage & Analysis Group (CAG), Centers for Medicare and Medicaid Services (CMS) since 2009 • Led CMS collaborations with Food and Drug Administration (FDA) including Entrepreneurs in Residence Program • Practiced medicine as an attending physician for almost 20 years, and was an Associate Dean at Georgetown University School of Medicine before coming to CMS Passionate about Change and Innovation • Implemented Coverage with Evidence Development (CED) under the Medicare program • Co-created joint parallel review pilot between CMS and FDA • Responsible for updating Medicare coverage in FDA IDE trials • Coauthored over 60 Medicare National Coverage Determinations • Developed program oversight of the Local Coverage Determination process Recognized as a Leader, Speechifier, and Writer • Invited speaker at national policy and professional society meetings nationally and abroad • Authored or coauthored original research and commentaries in peer reviewed medical journals • Awarded FDA Leveraging/Collaboration Award (TVT Registry Team) 2013; FDA Parallel Review Team Award 2012; CMS Leadership Awards 2006, 2010; Golden Apple (Teaching Award - Georgetown University School of Medicine) • Senior Vice President and Chief Innovation Officer Louis Jacques leads ADVI's growth efforts at the FDA, in pre-launch clinical trial development and measurement of clinical effectiveness and utility. Louis is spearheading an all client initiative focused on a top down commitment to change, recognizing that public and private payer "pay for value constructs" will require evidencing value and tying remuneration of our client's offerings to the evidencing of that value. Jacques is also a Senior Advisor to Warburg Pincus. Dr. Jacques is a graduate of Georgetown University and The University of Maryland School of Medicine.

11. Tamar Thompson Broad Cross-Specialization • Kimbell & Associates, a premier lobbying firm • Avalere, a leading advisory services firm • GE • Bracco Diagnostics • Molecular Insight Pharmaceuticals Extensive experience • Government agencies (HHS, CMS, FDA, PCORI, MEDPAC, MACPAC, IOM, OMB, CBO) • Private payers • Congressional leaders • Patient and Physician Stakeholders Involvement in scoring and legislative drafting Leader in quality, health economics, and value-based purchasing concepts • Vice President Tamar Thompson is a Vice President at ADVI and leads agency engagement across firm specializations. She has more than 15 years of leadership experience in health care, including the ability to develop strategic and tactical recommendations to ensure optimal reimbursement and market access for products. Ms. Thompson holds a M.S. in Health Sciences with a concentration in Public Health from Trident University in Cypress California. She also has active certifications from the American Health Information Management Association (AHIMA) as a Certified Coding Specialist (CCS) and Certified Coding Specialist – Physician Based (CCS-P).

12. ADVI.COM 202 509 0760 610 10TH STREET N.W. SUITE 400 WASHINGTON, DC 20001 WASHINGTON DC AUSTIN SAN FRANCISCO