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Avian Influenza. - The Human Health Perspective Dr. Andrew Larder FRCPC. Overview. Influenza – the virus Why you should be concerned Why I am concerned What we can do. Basic Influenza Facts. Human vs. Avian Influenza. Overview. Influenza – the virus Why you should be concerned

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avian influenza

Avian Influenza

- The Human Health Perspective

Dr. Andrew Larder FRCPC

overview
Overview
  • Influenza – the virus
  • Why you should be concerned
  • Why I am concerned
  • What we can do
overview1
Overview
  • Influenza – the virus
  • Why you should be concerned
  • Why I am concerned
  • What we can do
avian influenza and human exposure
Avian Influenza and Human Exposure
  • Poultry exquisitely susceptible
  • Large numbers of birds in confined spaces – Petri dish
  • Vast numbers of virus particles
    • Secretions, feathers, litter, walls, dust
    • Genetically diverse
avian influenza and human disease2
Avian Influenza and Human Disease
  • Infected poultry spread avian viruses to poultry workers
  • Multiple viruses can cause human illness
  • Both HP and LP can cause illness
  • Serious illness and person to person spread can occur
overview2
Overview
  • Influenza – the virus
  • Why you should be concerned
  • Why I am concerned
  • What we can do
pandemic influenza
Pandemic Influenza

an epidemic occurring world-wide, or over a very large area, affecting a large number of people

  • Novel virus
    • Frequent human exposure
    • No previous immunity
  • Ability to cause illness
  • Ability to spread person to person efficiently
influenza pandemics through the ages
Influenza Pandemics Through the Ages

Asian H2N2 SAR = 67%, CAR = 31% Case fatality = 0.5% Deaths = 3-7 million

Hong Kong H3N2 SAR = 65%, CAR = 21% Case fatality = 0.2% Deaths = 1-3 million

Spanish H1N1 Case fatality = 3.25% Deaths = 20-50 million

Average Interval Between Pandemics = 39 years (95% CI 8-70 years)

pandemic a possible scenario
Pandemic – A Possible Scenario
  • PW exposed to large numbers of genetically shifting AI
  • PW and families become infected
  • Human infections allow adaptation to human host
    • increasing ability to infect, and spread person to person
  • PW and families disseminate pandemic strain to population at large
pandemic it will happen
Pandemic – It Will Happen
  • When
  • Where
  • Which Virus
  • Who
  • How Severe
  • Utility of antivirals
  • Effectiveness of vaccine
what can we do
What Can We Do?
  • The canary in the coal mine approach

OR

  • Be aggressively proactive
    • Stop poultry from getting infected
    • Prevent PW from getting infected with AI
      • PPE, antiviral medications, vaccination, surveillance