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Diabetes - PowerPoint PPT Presentation


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slide1

Insulinoterapia

Carrera de Enfermería

Farmacología 17 de mayo 2010

Terapia Farmacológica en Diabetes Mellitus

EU-Lic. Rene Castillo Flores

Unidad de Fisiología y Farmacología

Universidad Santo Tomás

Sede Temuco - Chile

slide2

Historia

  • 1921, Los fisiólogos canadienses Frederick G. Banting y Charles H. Best extrajeron por primera vez la insulina del tejido pancreático de los perros.
slide3

Historia

  • 1922, administraron 15 ml de insulina exógena a un paciente diabético Leonard Thompson y su glicemia disminuyó de 440 a 320 mg/dL.
  • 1923 Premio Nóbel de Medicina descubrimiento de la insulina, MacLeod y Banting.
slide4

Década 50

Insulina lenta

Década 40

Protamina Neutra Hagedorn (NPH)

Década 30

Insulina Protamina Zinc (PZI),

Historia

slide5

Historia

1996

FDA aprobó el primer

análogo de insulina la Lispro

Década 80

Análogos de insulina

(ADN recombinante)

Década

60-70

Insulinas purificadas.

islotes de langerhans

PANCREAS

Acinos pancreáticos

Células δ 5-10% (somatostatina)

Célula α 20% (glucagon)

Célula β (insulina) 70%

Islotes de Langerhans