I mmunity. BY GHADA FAWZY. Innate immunity. Definition: Non specific early line of defense , it is the first line ofdefense against infection. This prevent entery of micro-organisms, or they eliminate them prior to occurance of the disease. Elements of innate immunity.
Non specific early line of defense , it is the first line ofdefense against infection. This prevent entery of micro-organisms, or they eliminate them prior to occurance of the disease
1- preserving normal epithelium by promoting epithelial growth&angiogenesis.
2- secreted by moist airway epithelium as biofilm
3- act as chemokines attract neutrophils,dendreticcells&Tlymphocytes
4- antimicrobial activity: desrupting membrane integrity of their victims&interact with negatively charged targets within the microbes
The end result is the production of a key enzyme (C3 convertase C3a&C3b , C4a, C5a.
Surface glycoproteinswhich are important in the interaction of lymphocytes with APC, keratinocytes, endothelial cells and also in their trafficking in skin during inflammation
Eg.: Cadherins, Ig, integrin, selectins
monocytes¯ophages(have Rs for IgGFc, C, interferon, TNF and some bacterial componentsphagocytosis.
STRESS INDUCED GLYCOPROTEIN
KILLER ACTIVATING RECEPTOR
+ + + +
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KILLER INHIBITORY RECEPTOR
Antigen: a substance that react with antibody or antigen receptors on lymphocytes.
Epitopes: the actual portion of antigen that react with antibodies or lymphocyte Rs.
- the epitope Rs on B lymphocyte (BCR- sIg)& on T lymphocytes (TCR)
Hapten: low molecular weight chemicals unable to provoke immune response unless they combine with protein
Superantigen: unusual bacterial toxins bind directly to outside of MHC-ІІ & activate large number of T4 lymphocytes
IL2,IFNδ,TNF --- IL2,4.5.10,13
cell mediated humoral
activate CTL,NK production of Igs
¯ophages &activate eoinophils
Th3: has suppressive effect on Th1&2
with production of IgE
Antigens located on HLA gene on chromosome 6