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Biology 1060 Chapter 16

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Biology 1060 Chapter 16

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  1. Biology 1060Chapter 16 Molecular Basis of Inheritance

  2. DNA • Describe the significance of DNA • Name the current model of DNA and its discoverers • List the requirements for genetic material and the likely candidates • Science, Technology, and Society p. 308

  3. Evidence for DNA • Describe Griffiths experiment and its implications • Discuss the experiments showing it was DNA • Describe the Hershey and Chase experiment • How did it differentiate protein from DNA • Discuss Chargaff’s rule and its implication

  4. Structural Model of DNA • Describe the evidence Watson and Crick needed to infer the requirements for a DNA model • Who provided this evidence? • Discuss the features of the DNA model • Locate each component and discuss the bonding patterns • Discuss how this model explains Chargaff’s rule

  5. DNA Replication • Describe semiconservative replication • Discuss the experiments of Meselson and Stahl • Describe how prokaryote and eukaryote replication differs • Scientific Inquiry p. 308

  6. Details of DNA Replication • Describe the origins of replication • Describe elongation of DNA and its control • Discuss antiparallel elongation • Differentiate between leading and lagging strands, Okazaki fragments

  7. Assisting DNA Replication • Describe the molecules required to prime DNA replication • Describe the enzymes responsible for establishing and maintaining the separation of the two DNA strands • Discuss the possibility that DNA replication machinery is stationary and complex

  8. Proofreading and Repair • Describe how mismatched strands can be repaired • Discuss the significance of telomeres in cell division • Evolution Connection p. 308