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Understanding ECF Sigma Factors in Bacterial Stress Adaptation

Learn about the role of Extra-cytoplasmic Function (ECF) sigma factors in regulating stress adaptation gene products, with insights on ECF sigma families, regulatory mechanisms, and conserved sequences.

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Understanding ECF Sigma Factors in Bacterial Stress Adaptation

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  1. Common Features of Extracytoplasmic Function (ECF)  Factors signal anti-sigma  sig ECF P P P P sigECF regulon

  2. 3970799 3965800 Py yxlD yxlF yxlH sigY yxlE yxlG yxlA yxlC sigY operon • Extra-cytoplasmic function (ECF) sigma factors regulate expression of gene products involved in stress adaptation • Sequence homology to other known ECF sigmas identified seven Bacillus subtilis paralogs • ECF sigmas from several bacterial species have been shown to be auto- transcribed • -35-10 • Sig W tGaAAC CGT(a/c) • Sig X tGtAAC CG(a/t)C • Sig Y aTGAAC CGTC

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