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This article explores the significance of Vascular Endothelial Growth Factor Receptor 2 (VEGFR-2) in cell signaling pathways. It discusses the mechanisms of VEGFR-2 activation, its interaction with Src family kinases, and the implications for angiogenesis and tumor progression. The findings reveal the complex regulatory roles of various kinases in modulating VEGFR-2 activity, highlighting potential therapeutic targets for cancer treatment and vascular diseases. Insights into VEGFR-2's structure and function deepen our understanding of its role in biological processes.
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C-V C+V C+KI+V D+V A. B. C-V C+V C+KI+V IB: pSrc 418 p-Src Src pVEGFR-2 IB: Src IB: pVEGFR-2 (1175) Fold of p-Src (418)