T Cell Receptors . By: Alexander Ko , David Lam, Caddie Sze and Vicky Yee Date: November 4 th , 2013. PHM142 Fall 2013 Coordinator: Dr. Jeffrey Henderson Instructor: Dr. David Hampson. What is T Cell Receptor.
By: Alexander Ko, David Lam, Caddie Sze and Vicky Yee
Date: November 4th, 2013
PHM142 Fall 2013
Coordinator: Dr. Jeffrey Henderson
Instructor: Dr. David Hampson
Figure 3.13The crystal structure of an α:β T-cell receptor resolved at 2.5 Å
What would happen if pathogens bound at relatively high affinities?
Morrison, L.A., Lukacher, A.E., Braciale, V.L., Fan, D.P. and Braciale, T.J. (1986) Differences in antigen presentation to MHC class I- and MHC Class II-restricted influenza virus-specific cytolytic T-lymphocyte clones. Journal of Experimental Medicine. 163: 903
"Major Histocompatibility Complex." Protein Data Bank. N.p., Feb. 2005. Web. 15 Oct. 2013.
Source 1: http://harunyahya.com/en/Books/989/the-miracle-of-the-immune/chapter/3768
Source 2: http://arthritis-research.com/content/11/1/202/figure/f1?highres=y
Defective VDJ recombination of TCR
Defective binding of TCR & MHC
Adapted from “Janeway’sImmunobiology 8th edition,” by K. Murphy, 2012, Garland Science p. 522